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Other Sizes |
Promegestone (R-5020; RU-5020; trade name Surgestone) is a synthetic progestogen that functions as an agonist of the progesterone receptor and a progestin drug. It's been applied to the treatment of gynecological disorders and menopausal hormone therapy.
ln Vitro |
Promegestone (R-5020; 1 nM) is an effective ligand in HELN-hPR, exhibiting a complete agonist response profile and a low EC50 of 0.33 nM. However, in U2OS-zfPR, it only partially induced luciferase activity (EC50=1.93 nM)[1].
Promegestone is inactive in HeLa cells with luciferase expression but no functional receptor[1].
Promegestone (10 nM) robustly increases the expression of SLC37A2 in T47D cell models in cells expressing SUMO-deficient PR, but not in cells expressing WT PR[3].
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ln Vivo |
Promegestone (R-5020; 8 mg/kg; intramuscularly)-treated pregnant mice have the highest cell density and the least amount of extracellular collagen deterioration (lowest OD) on day 18 postbreeding when compared to other groups on the day before birth[2].
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References |
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Molecular Formula |
C22H30O2
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Molecular Weight |
326.48
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Exact Mass |
326.2246
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Elemental Analysis |
C, 80.94; H, 9.26; O, 9.80
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CAS # |
34184-77-5
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Appearance |
Solid powder
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SMILES |
CCC(=O)[C@]1(CC[C@@H]2[C@@]1(CCC3=C4CCC(=O)C=C4CC[C@@H]23)C)C
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InChi Key |
QFFCYTLOTYIJMR-XMGTWHOFSA-N
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InChi Code |
InChI=1S/C22H30O2/c1-4-20(24)22(3)12-10-19-18-7-5-14-13-15(23)6-8-16(14)17(18)9-11-21(19,22)2/h13,18-19H,4-12H2,1-3H3/t18-,19+,21+,22-/m1/s1
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Chemical Name |
(8S,13S,14S,17S)-13,17-dimethyl-17-propanoyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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Synonyms |
Surgestone; Promegestone; R 5020; R-5020; R5020; RU 5020; RU5020; RU-5020; U56217;U 56217; U-56217
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HS Tariff Code |
2934.99.03.00
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.0630 mL | 15.3149 mL | 30.6297 mL | |
5 mM | 0.6126 mL | 3.0630 mL | 6.1259 mL | |
10 mM | 0.3063 mL | 1.5315 mL | 3.0630 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.