| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| Other Sizes |
| Targets |
HCV NS5A protein. However, this degradation product has significantly reduced antiviral activity compared to the parent drug. It serves as an impurity marker rather than a therapeutic agent.
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| ln Vitro |
Monodes(N‑carboxymethyl)valine Daclatasvir TFA does not exhibit significant biological activity itself. It is a non‑active degradation product. Its detection and quantification in pharmaceutical formulations is crucial for ensuring the stability and quality of Daclatasvir drug products.
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| Enzyme Assay |
A general cell‑free protocol for Monodes(N‑carboxymethyl)valine Daclatasvir TFA is not applicable, as it is not used in biological assays. As a reference standard, its identity and purity are confirmed by HPLC, LC‑MS, and NMR spectroscopy.
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| Cell Assay |
General cellular protocol for Monodes(N‑carboxymethyl)valine Daclatasvir TFA is not applicable. It is not used in cell‑based studies. Its primary application is in the chemical analysis of Daclatasvir drug substances and products.
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| Animal Protocol |
General animal protocol for Monodes(N‑carboxymethyl)valine Daclatasvir TFA is not applicable. This compound is not used in animal studies. It serves only as a chemical reference standard for degradation product analysis.
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| ADME/Pharmacokinetics |
General PK protocol for Monodes(N‑carboxymethyl)valine Daclatasvir TFA is not applicable. This degradation product is not a therapeutic agent, and its pharmacokinetics are not studied. It is only used as a benchmark for analytical testing.
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| Toxicity/Toxicokinetics |
General toxicity protocol for Monodes(N‑carboxymethyl)valine Daclatasvir TFA is not applicable. As an impurity and a reference standard, it is not dosed in animals for toxicity studies. The compound is classified as a laboratory reagent and should be handled with standard safety precautions.
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| References | |
| Additional Infomation |
Monodes(N‑carboxymethyl)valine Daclatasvir TFA has the molecular formula C3₅H40F3N₇O₅ and a molecular weight of 695.73 g/mol. The compound is stored at 4degC in a sealed, dry container. In solution, it can be stored at -80degC for up to 6 months. It is an important reference material for generic drug development and for the mandatory stability testing of Daclatasvir formulations.
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| Molecular Formula |
C35H40F3N7O5
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|---|---|
| Molecular Weight |
695.73
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| Appearance |
Solid powder
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| Synonyms |
Daclatasvir Impurity A TFA
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (143.73 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4373 mL | 7.1867 mL | 14.3734 mL | |
| 5 mM | 0.2875 mL | 1.4373 mL | 2.8747 mL | |
| 10 mM | 0.1437 mL | 0.7187 mL | 1.4373 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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