| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Toralactone does not have a well-characterized specific biological target. As a naturally occurring coumarin derivative, it may interact with various enzymes and receptors. Coumarins are known to have a wide range of biological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. Further studies are needed to elucidate the specific molecular targets of toralactone.
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| ln Vitro |
Toralactone inhibits P-glycoprotein efflux activity, which makes the resistant MCF-7adr cell line more susceptible to paclitaxel[2].
In vitro studies of toralactone are limited. As a naturally occurring compound, it may be studied for its potential biological activities, such as antioxidant or antimicrobial properties. Coumarin derivatives are known to have various in vitro activities, and toralactone may be investigated for similar properties. Further research is needed to characterize its in vitro activity profile. |
| ln Vivo |
In vivo activity data for toralactone are limited. As a naturally occurring compound, it may be studied in animal models for its potential therapeutic effects. Coumarin derivatives have been studied for their anti-inflammatory, anticoagulant, and anticancer activities in vivo. Further research is needed to evaluate the in vivo efficacy and safety of toralactone.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for toralactone are not well-established. As a coumarin derivative, it may be studied for its interaction with enzymes such as cytochrome P450s or with receptors such as the aryl hydrocarbon receptor. Further research is needed to develop specific assays for studying the molecular interactions of toralactone.
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| Cell Assay |
In vitro cell-based assays for toralactone are not well-established. As a naturally occurring compound, it may be studied in cell lines for its potential cytotoxic, anti-inflammatory, or antioxidant activities. Further research is needed to characterize its effects on various cell types and to identify its mechanism of action.
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| Animal Protocol |
In vivo animal studies for toralactone are not well-established. As a naturally occurring compound, it may be studied in animal models for its potential therapeutic effects. Further research is needed to evaluate its pharmacokinetics, efficacy, and safety in vivo.
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| ADME/Pharmacokinetics |
Toralactone has a molecular formula of C15H12O5 and a molecular weight of 272.26. The CAS number is 41743-74-2. The compound has a melting point of 252-254°C. It appears as a pale yellow solid. It should be stored desiccated at -20°C. It is intended for research use only.
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| Toxicity/Toxicokinetics |
The toxicity profile of toralactone is not extensively characterized. As a naturally occurring compound, it may have a favorable safety profile, but further studies are needed to evaluate its toxicity. The compound is intended for research use only and is not approved for therapeutic use in humans. Standard laboratory safety practices should be followed.
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| References |
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| Additional Infomation |
Toranolone is an organic heterocyclic tricyclic compound with the structure 9,10-dihydroxy-1H-benzo[g]isochromen-1-one, where the 3 and 7 positions are substituted with methyl and methoxy groups, respectively. It is a plant metabolite. Toranolone belongs to the organic heterocyclic tricyclic compounds, lactones, phenolic compounds, aromatic ethers, polyketides, and naphtho-α-pyranones. Its function is related to nortoranolone. Toranolone has been reported in both Senna obtusifolia and Senna tora.
Toralactone (CAS 41743-74-2) is a naturally occurring coumarin derivative primarily isolated from plants in the Angelica and Ferula genera. It is an organic heterotricyclic compound that is 9,10-dihydroxy-1H-benzo[g]isochromen-1-one substituted at positions 3 and 7. It has a molecular formula of C15H12O5 and a molecular weight of 272.26. |
| Molecular Formula |
C15H12O5
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|---|---|
| Molecular Weight |
272.25
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| Exact Mass |
272.068
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| CAS # |
41743-74-2
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| PubChem CID |
5321980
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| Appearance |
Off-white to yellow solid powder
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| Density |
1.432g/cm3
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| Boiling Point |
480.2ºC at 760mmHg
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| Melting Point |
252 - 254 °C
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| Flash Point |
184.8ºC
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| Index of Refraction |
1.691
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| LogP |
2.674
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
20
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| Complexity |
432
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=CC(O)=C2C(=C3C(=O)OC(C)=CC3=CC2=C1)O
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| InChi Key |
WEHXAEGTVPWKDY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H12O5/c1-7-3-8-4-9-5-10(19-2)6-11(16)12(9)14(17)13(8)15(18)20-7/h3-6,16-17H,1-2H3
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| Chemical Name |
9,10-dihydroxy-7-methoxy-3-methylbenzo[g]isochromen-1-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO :~2.5 mg/mL (~9.18 mM )
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6731 mL | 18.3655 mL | 36.7309 mL | |
| 5 mM | 0.7346 mL | 3.6731 mL | 7.3462 mL | |
| 10 mM | 0.3673 mL | 1.8365 mL | 3.6731 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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