| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 500mg |
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| Other Sizes |
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Purity: ≥98%
| Targets |
Human Endogenous Metabolite
|
|---|---|
| ln Vitro |
The activation of the NLRP3 inflammasome in HGFs is enhanced when ATP disodium trihydrate (5 mM; 1 hour) and LPS (1 μg/mL) are treated together [3]. In a manner that is dependent on caspase-1 activation, ATP disodium trihydrate (2 mM; 0.5-24 hours) causes BMDM to release KC, MIP-2, and IL-1β [4]. Chemotaxis of neutrophils is facilitated by ATP disodium trihydrate [4].
|
| ln Vivo |
In vivo, mice are protected against bacterial infection by ATP disodium trihydrate (50 mg/kg; ip) [4]. In vivo, ATP disodium trihydrate stimulates the release of KC, MIP-2, and IL-1β as well as the recruitment of neutrophils [4].
|
| Animal Protocol |
Animal/Disease Models: Fourweeks old Kunming mice (18-22 g)[4]
Doses: 50 mg/kg Route of Administration: intraperitoneal (ip)injection, before bacterial (E. coli) challenge Experimental Results: Protected mice from bacterial infection. |
| References |
|
| Additional Infomation |
See also: Sodium ATP (annotation moved to).
|
| Molecular Formula |
C10H20N5NA2O16P3
|
|---|---|
| Molecular Weight |
605.19
|
| Exact Mass |
550.959
|
| CAS # |
51963-61-2
|
| Related CAS # |
ATP disodium salt;987-65-5;ATP;56-65-5;ATP dimagnesium;74804-12-9;ATP disodium salt hydrate;34369-07-8;ATP dipotassium;42373-41-1;ATP ditromethamine;102047-34-7;ATP-13C dilithium;ATP-15N5,d14 dilithium;ATP-d14 dilithium;ATP-15N5 dilithium;ATP-13C10 dilithium
|
| PubChem CID |
22799238
|
| Appearance |
White to off-white solid powder
|
| Melting Point |
176ºC
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
17
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
35
|
| Complexity |
772
|
| Defined Atom Stereocenter Count |
4
|
| SMILES |
C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)O)N.[Na+].[Na+].[Na+].[Na+]
|
| InChi Key |
MWEQTWJABOLLOS-AZGWGOJFSA-L
|
| InChi Code |
InChI=1S/C10H16N5O13P3.2Na.3H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;3*1H2/q;2*+1;;;/p-2/t4-,6-,7-,10-;;;;;/m1...../s1
|
| Chemical Name |
disodium;[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;trihydrate
|
| Synonyms |
51963-61-2; ADENOSINE 5'-TRIPHOSPHATE DISODIUM SALT TRIHYDRATE; Adenosine 5'-(tetrahydrogen triphosphate), disodium salt, trihydrate; disodium;[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;trihydrate; Adenosine triphosphate disodium salt; Adenosine 5'-triphosphate disodium salt; sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogentriphosphate trihydrate; Adenosine-5'-triphosphate disodium salt trihydrate;
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O :~250 mg/mL (~413.09 mM)
DMSO :~1 mg/mL (~1.65 mM (<80°C)) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (82.62 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6524 mL | 8.2619 mL | 16.5237 mL | |
| 5 mM | 0.3305 mL | 1.6524 mL | 3.3047 mL | |
| 10 mM | 0.1652 mL | 0.8262 mL | 1.6524 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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