| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
| Targets |
The unlabeled compound, MSM, targets key inflammatory mediators and oxidative stress pathways, including inhibition of NF-kappaB activation. The labeled d6 analog is not typically used for target identification but rather as an analytical internal standard for quantifying unlabeled MSM in various matrices.
|
|---|---|
| ln Vitro |
In vitro, Dimethyl sulfone-d6 is primarily used as an internal standard in analytical methods rather than as a pharmacological agent. Unlabeled MSM demonstrates anti-inflammatory properties by reducing TNF-alpha, IL-6, and NO production in cell cultures.
|
| ln Vivo |
In vivo, the compound is used as a tracer and internal standard in pharmacokinetic studies of MSM in animals and humans. Unlabeled MSM has demonstrated anti-inflammatory and joint-protective effects in animal models of arthritis.
|
| Enzyme Assay |
A typical non-cell assay involves using Dimethyl sulfone-d6 as an internal standard for GC-MS or LC-MS quantification of MSM. A fixed concentration (e.g., 10 uM) is added to all standards and samples to normalize for extraction efficiency and instrument variability.
|
| Cell Assay |
Cellular assays are not typical for this deuterated compound. In some experimental designs, Dimethyl sulfone-d6 (unlabeled) may be incubated with cells such as primary chondrocytes or macrophages to study its effects on inflammatory cytokine production. The d6 version is not intended for such use.
|
| Animal Protocol |
In animal studies, the compound is typically administered orally to rodents as part of a dosing solution (e.g., 1,000-2,000 mg/kg). Plasma samples collected at various time points are spiked with Dimethyl sulfone-d6 as the internal standard for LC-MS/MS quantification of circulating MSM levels.
|
| ADME/Pharmacokinetics |
MSM (unlabeled) is rapidly absorbed after oral administration with a half-life of approximately 12 hours. The deuterated form has identical ADME properties and is excreted primarily in urine. The deuterium label does not significantly alter its pharmacokinetic profile.
|
| Toxicity/Toxicokinetics |
MSM has extremely low toxicity, with an LD₅0 > 17 g/kg in rodents. It is generally recognized as safe (GRAS) by the FDA. Minor gastrointestinal side effects may occur at very high doses. The deuterated analog is considered non-toxic for research use.
|
| References | |
| Additional Infomation |
See also: Dimethyl sulfone (note moved to).
This compound is not an approved drug but is widely used as an internal standard for analytical method development, particularly in food analysis and supplement quality control. It also serves as a reference standard for qNMR purity assignment of other organic compounds. |
| Molecular Formula |
C2D6O2S
|
|---|---|
| Molecular Weight |
100.17
|
| Exact Mass |
100.046
|
| CAS # |
22230-82-6
|
| Related CAS # |
Dimethyl sulfone;67-71-0
|
| PubChem CID |
16213553
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
240.9±8.0 °C at 760 mmHg
|
| Melting Point |
107-109ºC(lit.)
|
| Flash Point |
143.3±0.0 °C
|
| Vapour Pressure |
0.1±0.5 mmHg at 25°C
|
| Index of Refraction |
1.402
|
| LogP |
-1.19
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
5
|
| Complexity |
85.3
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
[2H]C([2H])([2H])S(=O)(=O)C([2H])([2H])[2H]
|
| InChi Key |
HHVIBTZHLRERCL-WFGJKAKNSA-N
|
| InChi Code |
InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3/i1D3,2D3
|
| Chemical Name |
trideuterio(trideuteriomethylsulfonyl)methane
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.9830 mL | 49.9151 mL | 99.8303 mL | |
| 5 mM | 1.9966 mL | 9.9830 mL | 19.9661 mL | |
| 10 mM | 0.9983 mL | 4.9915 mL | 9.9830 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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