| Size | Price | Stock | Qty |
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| 5mg |
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| Other Sizes |
| Targets |
Angiotensin II receptor type 1 (AT1R) is the primary target of Olmesartan, the parent drug. Olmesartan is a potent and specific angiotensin II receptor (AT1R) antagonist used in the treatment of hypertension. Dehydro Olmesartan is a derivative of Olmesartan and is expected to exhibit activity related to AT1 receptor antagonism. However, as an impurity, its primary relevance is in analytical chemistry rather than as a pharmacologically active compound.
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| ln Vitro |
In vitro, as a derivative of Olmesartan, Dehydro Olmesartan is expected to exhibit activity related to AT1 receptor antagonism. Olmesartan itself is a potent and specific AT1 receptor antagonist. Dehydro Olmesartan, as a related compound, may be studied for similar effects in research settings. However, the compound is primarily used as an impurity standard rather than for pharmacological studies.
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| ln Vivo |
In vivo, Olmesartan demonstrates antihypertensive activity. Dehydro Olmesartan, as a related compound, may be studied for similar effects. However, as an impurity, the compound is not typically studied for pharmacological activity but rather for quality control purposes.
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| Enzyme Assay |
The in vitro enzyme/receptor binding (cell-free) assay for Dehydro Olmesartan is not typically performed, as the compound is primarily used as an impurity standard. However, radioligand binding assays using membrane preparations from cells expressing AT1 receptors could be performed to determine the binding affinity of Olmesartan and related compounds. Dehydro Olmesartan may be evaluated in similar assays for research purposes.
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| Cell Assay |
Cell-based assays are not typically performed for impurities. The compound is used as a reference material in analytical testing. Functional assays measuring angiotensin II-induced signaling in cells expressing AT1 receptors could be used to evaluate antagonist activity if needed for research purposes.
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| Animal Protocol |
In vivo studies are not typically performed for impurities. The compound is used as a reference standard in pharmaceutical quality control. Animal models of hypertension could be used to evaluate the antihypertensive effects of Olmesartan and related compounds if needed for research purposes.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Dehydro Olmesartan are not typically studied. Olmesartan itself is the active pharmaceutical ingredient with well-characterized PK. Olmesartan is eliminated by both hepatic and renal pathways, with about 60% eliminated by the liver and the remainder by the kidney. Dehydro Olmesartan may share similar properties if it is formed as a metabolite or impurity.
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| Toxicity/Toxicokinetics |
Toxicology data for Dehydro Olmesartan are evaluated as part of pharmaceutical impurity profiling to ensure safety at trace levels in drug products. The compound is an impurity of Olmesartan Medoxomil, and its presence and characterization are crucial for ensuring the purity and efficacy of the final pharmaceutical product. The safety of the impurity is assessed based on its concentration in the final drug product.
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| References |
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| Additional Infomation |
Dehydro Olmesartan (CAS: 172875-98-8) is a chemical compound related to the antihypertensive drug Olmesartan. It may be used as a reference standard or in impurity profiling. The compound has a molecular formula of C24H24N6O2 and a molecular weight of 428.49. Dehydro Olmesartan is not a therapeutic agent and is not approved for human use. The compound is intended for research and quality control purposes only.
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| Molecular Formula |
C24H24N6O2
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|---|---|
| Molecular Weight |
428.49
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| Exact Mass |
428.196
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| CAS # |
172875-98-8
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| PubChem CID |
9888820
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| Appearance |
White to off-white solid powder
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| LogP |
4.462
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
32
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| Complexity |
652
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)C(=C)C
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| InChi Key |
LLECTTOFSXVBBY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C24H24N6O2/c1-4-7-20-25-21(15(2)3)22(24(31)32)30(20)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)23-26-28-29-27-23/h5-6,8-13H,2,4,7,14H2,1,3H3,(H,31,32)(H,26,27,28,29)
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| Chemical Name |
5-prop-1-en-2-yl-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3338 mL | 11.6689 mL | 23.3378 mL | |
| 5 mM | 0.4668 mL | 2.3338 mL | 4.6676 mL | |
| 10 mM | 0.2334 mL | 1.1669 mL | 2.3338 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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