| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| 10g |
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| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
When used in combination with other ingredients in suppository form, absorption into the bloodstream is minimal. However, applying creams or ointments to open wounds or skin may result in absorption and entry into the bloodstream. Metabolism/Metabolites Following oral administration of aescin (100 mg/kg) to rats, plasma, urine, feces, and bile samples were collected to screen for metabolites. A total of 19 metabolites were identified (10 phase I metabolites and 9 phase II metabolites). The study also found that after oral administration of aescin, it can be metabolized in vivo to aescinol via deglycosylation, and aescinol was detected in all biological samples. Biological Half-Life The absorption half-life is approximately 1 hour, and the elimination half-life is approximately 20 hours. |
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| References |
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| Additional Infomation |
Aescin is a hydroxycoumarin, a 6-O-β-D-glucoside of aescin. It has antioxidant and metabolic effects. It is a β-D-glucoside and hydroxycoumarin, functionally related to aescin. Aescin is found in barley. Vitamin C2 is generally considered a bioflavonoid, associated with vitamin P. Aescin is a glucoside naturally found in the dark green resin of Aesculus hippocastanum, Aesculus californica, and Daphne mezereum. Aescin belongs to the glycoside family. These are carbohydrate derivatives in which one glycosyl group is linked to another glycosyl group via a C-, S-, N-, O-, or Se-glycosidic bond through its non-glycosyl carbon atom. Aescin has been reported in Gardenia jasminoides, Ixeridium laevigatum, and other organisms with relevant data. It is a derivative of coumarin, with the molecular formula C15H16O9. See also: Aesculus (part); Aesculus bark (part). Pharmacological Indications Aesculin is sometimes used as a vascular protectant. It is also used in microbiology laboratories to aid in the identification of bacterial species (especially Enterococci and Listeria), as all Group D Streptococcus strains can hydrolyze aesculin in 40% bile. Mechanism of Action Aesculin's primary function is to protect capillaries by improving their permeability and fragility. It has been reported to inhibit catabolic enzymes such as hyaluronidase and collagenase, thereby maintaining the integrity of perivascular connective tissue. Aesculin also exhibits good antioxidant properties, protecting triglycerides from autoxidation at high temperatures. These antioxidant properties may also explain its anti-inflammatory activity, making it an ideal product for after-sun care.
Pharmacodynamics Topical application of aescin can increase "capillary density" (the number of open, flowing capillaries per unit surface area) and improve the morphology of the smallest vessels. |
| Molecular Formula |
C30H38O21
|
|---|---|
| Molecular Weight |
367.31
|
| Exact Mass |
358.089
|
| CAS # |
66778-17-4
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| Related CAS # |
Esculin;531-75-9
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| PubChem CID |
5281417
|
| Appearance |
White to off-white solid
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| Density |
0.791 g/mL at 20 °C
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| Melting Point |
203-205 °C
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| LogP |
-0.6
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| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
9
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
24
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| Complexity |
495
|
| Defined Atom Stereocenter Count |
5
|
| SMILES |
O1[C@]([H])([C@@]([H])([C@]([H])([C@@]([H])([C@@]1([H])C([H])([H])O[H])O[H])O[H])O[H])OC1=C(C([H])=C2C(C([H])=C([H])C(=O)O2)=C1[H])O[H].O1[C@]([H])([C@@]([H])([C@]([H])([C@@]([H])([C@@]1([H])C([H])([H])O[H])O[H])O[H])O[H])OC1=C(C([H])=C2C(C([H])=C([H])C(=O)O2)=C1[H])O[H].O([H])[H].O([H])[H].O([H])[H]
|
| InChi Key |
XHCADAYNFIFUHF-TVKJYDDYSA-N
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| InChi Code |
InChI=1S/C15H16O9/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17/h1-4,10,12-17,19-21H,5H2/t10-,12-,13+,14-,15-/m1/s1
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| Chemical Name |
7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~10 mg/mL (~27.2 mM; with ultrasonication and warming by heating to 60°C)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (2.72 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (10.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1 mg/mL (2.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (10.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7225 mL | 13.6125 mL | 27.2250 mL | |
| 5 mM | 0.5445 mL | 2.7225 mL | 5.4450 mL | |
| 10 mM | 0.2722 mL | 1.3612 mL | 2.7225 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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