| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
| Targets |
Glycerol-d5 does not target a specific receptor or enzyme. Its utility lies in its function as a stable isotope-labeled internal standard and as a solvent for NMR spectroscopy. The deuterium atoms provide a distinct signal in ¹H-NMR, allowing for the use of glycerol-d5 as a reference or as a solvent in deuterium exchange experiments.
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|---|---|
| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
In vitro, glycerol-d5 is not used to study biological activity. It is used as a solvent in NMR spectroscopy to study the structure of biomolecules. It is also used in sample preparation and gel formation for polyacrylamide gel electrophoresis. |
| ln Vivo |
In vivo, glycerol-d5 is not administered as a therapeutic agent. It may be used in tracer studies to investigate glycerol metabolism, but its primary application is as an analytical tool and solvent.
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| Enzyme Assay |
Glycerol-d5 is not used in cell-free enzymatic or receptor binding assays. Its role is limited to analytical chemistry and spectroscopy.
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| Cell Assay |
In vitro cellular experiments with glycerol-d5 are not typically performed, as the compound is not used to treat cells. It may be added to cell culture media as a cryoprotectant or as a component of electrophoresis sample buffers.
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| Animal Protocol |
In vivo animal studies with glycerol-d5 are not typical. The compound is not administered to animals as a drug. However, it could be used in pharmacokinetic studies to trace the metabolism of glycerol if administered as part of a labeled tracer experiment.
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| ADME/Pharmacokinetics |
The pharmacokinetics of glycerol-d5 are expected to be identical to those of unlabeled glycerol. Glycerol is absorbed from the gastrointestinal tract, distributed throughout the body, and metabolized in the liver to glucose or oxidized to CO₂ and water. The deuterium label does not significantly alter the compound's chemical properties.
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| Toxicity/Toxicokinetics |
Glycerol-d5 is a stable isotope with no known toxicity. Glycerol is generally recognized as safe (GRAS) for use in food and pharmaceuticals. The deuterated form is considered safe for use in research applications.
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| References |
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| Additional Infomation |
Glycerol-d5 is a research compound with no clinical applications or regulatory approvals. It is used as a stable isotope-labeled internal standard and as a solvent for NMR spectroscopy. Its enhanced stability makes it valuable for various analytical and spectroscopic applications.
|
| Molecular Formula |
C3H3D5O3
|
|---|---|
| Molecular Weight |
97.12
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| Exact Mass |
97.078
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| CAS # |
62502-71-0
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| Related CAS # |
Glycerol;56-81-5
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| PubChem CID |
11768502
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.331 g/mL at 25ºC
|
| Boiling Point |
182ºC(lit.)
|
| Melting Point |
20ºC(lit.)
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| Flash Point |
320 °F
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| Index of Refraction |
n20/D 1.472(lit.)
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| LogP |
-1.8
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| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
6
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| Complexity |
25.2
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
C([2H])([2H])(C([2H])(C([2H])([2H])O)O)O
|
| InChi Key |
PEDCQBHIVMGVHV-UXXIZXEISA-N
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| InChi Code |
InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2/i1D2,2D2,3D
|
| Chemical Name |
1,1,2,3,3-pentadeuteriopropane-1,2,3-triol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 10.2965 mL | 51.4827 mL | 102.9654 mL | |
| 5 mM | 2.0593 mL | 10.2965 mL | 20.5931 mL | |
| 10 mM | 1.0297 mL | 5.1483 mL | 10.2965 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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