| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Human Endogenous Metabolite
Cellulose does not have a specific biological target as a therapeutic agent. It is an inert polysaccharide used primarily for its physical and chemical properties in pharmaceutical formulations and food products. In biological systems, it is not digested by humans and serves as dietary fiber. It may interact with the gastrointestinal tract as a bulking agent. |
|---|---|
| ln Vitro |
One possible use for cellulose is as a medicinal excipient. Other chemicals utilized in the pharmaceutical process besides medication components are referred to as pharmaceutical auxiliaries or excipients. Pharmaceutical preparations' inactive substances, which can increase their stability, solubility, and processability, are referred to as pharmaceutical excipients. The processes of concurrent medication absorption, distribution, metabolism, and elimination (ADME) can also be impacted by pharmaceutical excipients.
In vitro, cellulose is used as a support material in partition chromatography and as a component in cell culture media. It serves as a bulking agent, stabilizer, and texture improver in food products such as baked goods, cheese, and frozen desserts. Its inert nature makes it suitable for use in various pharmaceutical and cosmetic formulations. |
| ln Vivo |
In vivo, cellulose is not absorbed and passes through the gastrointestinal tract as dietary fiber. It plays a role in promoting regular bowel movements and may be used as a bulking agent in laxative formulations. In pharmaceutical applications, it is used as a tablet excipient and filler.
|
| Enzyme Assay |
In vitro assays involving cellulose typically measure its physical properties rather than biological activity. The compound is used as a support material for chromatographic separations and as a standard for assessing the activity of cellulase enzymes. Assays may involve incubating cellulose with cellulase and measuring the release of glucose or other products to assess enzymatic activity.
|
| Cell Assay |
In vitro cell experiments with cellulose are not commonly performed, as the compound is inert and not biologically active in mammalian cell cultures. However, cellulose may be used as a scaffold or support material in tissue engineering and 3D cell culture applications. Its biocompatibility and structural properties make it suitable for these applications.
|
| Animal Protocol |
In vivo animal experiments with cellulose are typically conducted to study its effects as dietary fiber. Animals are fed diets containing varying amounts of cellulose, and the effects on gastrointestinal transit, stool output, and metabolic parameters are assessed. Cellulose is also used as a control substance in studies evaluating the effects of other dietary fibers.
|
| ADME/Pharmacokinetics |
Cellulose is not absorbed from the gastrointestinal tract and is excreted in feces. As an inert polysaccharide, it does not exhibit classic pharmacokinetic properties. It is stable, non-toxic, and widely used as a pharmaceutical excipient. The compound is typically stored as a powder at room temperature.
|
| Toxicity/Toxicokinetics |
Toxicity Data
LC50 (Rat) > 5,800 mg/m³/4h Cellulose is generally recognized as safe (GRAS) and has a well-established safety profile. It is non-toxic and non-irritating, making it suitable for use in food, pharmaceutical, and cosmetic products. No significant toxicity has been reported with its use. The compound is intended for various applications and is not used as a therapeutic agent. |
| References | |
| Additional Infomation |
Cellulose is a tasteless, white, powdery fiber. Density: 1.5 g/cm³. It is a biopolymer that constitutes the cell walls of plant tissues. Preparation methods include treating cotton with organic solvents to remove waxes and extracting with sodium hydroxide solution to remove pectic acid. It is the main fiber constituting the cell walls of plant tissues (wood, cotton, flax, grass, etc.). Its technical applications depend on the strength and flexibility of the fiber. It is insoluble in water. It can be dissolved in sulfuric acid through chemical degradation and is also soluble in concentrated zinc chloride solution. It is soluble in aqueous copper ammonium hydroxide (Cu(NH₃)₄(OH)₂). β-Cellobiose refers to cellobiose with a β-configuration of glucose residues at the reducing end. It has epitope function. Cellobiose is a metabolite present in or produced by Escherichia coli (K12, MG1655 strains). D-Cellobiose has also been reported in Aspergillus niger, with relevant data available. Cellobiose is a metabolite present in or produced by Saccharomyces cerevisiae. A disaccharide consisting of two glucose units linked by a β(1-4) glycosidic bond. It is prepared by partial hydrolysis of cellulose.
Cellulose is a widely used excipient and food additive with applications in pharmaceuticals, food products, and material science. It is used as a bulking agent, stabilizer, and texture improver. Microcrystalline cellulose is a common tablet excipient and is used in various formulations. No clinical trials or therapeutic indications exist for cellulose itself, as it is an inert material used for its physical properties. |
| Molecular Formula |
C12H22O11
|
|---|---|
| Molecular Weight |
342.2965
|
| Exact Mass |
160.125
|
| CAS # |
9004-34-6
|
| Related CAS # |
Potassium clavulanate cellulose;Hydroxyethyl cellulose;9004-62-0;CM Cellulose CM-32;9000-11-7
|
| PubChem CID |
10712
|
| Appearance |
White to off-white solid powder
|
| Density |
0.9±0.1 g/cm3
|
| Boiling Point |
237.6±35.0 °C at 760 mmHg
|
| Melting Point |
260-270ºC
|
| Flash Point |
91.8±14.5 °C
|
| Vapour Pressure |
0.1±0.2 mmHg at 25°C
|
| Index of Refraction |
1.529
|
| LogP |
4.75
|
| Hydrogen Bond Donor Count |
8
|
| Hydrogen Bond Acceptor Count |
11
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
23
|
| Complexity |
382
|
| Defined Atom Stereocenter Count |
10
|
| SMILES |
C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O)CO)O)O)O)O
|
| InChi Key |
GUBGYTABKSRVRQ-QRZGKKJRSA-N
|
| InChi Code |
InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5-,6+,7-,8-,9-,10-,11-,12+/m1/s1
|
| Chemical Name |
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9214 mL | 14.6071 mL | 29.2141 mL | |
| 5 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL | |
| 10 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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