| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
| Targets |
Hydroxyethyl cellulose does not have a specific pharmacological target. It functions as a viscosity-increasing agent and a stabilizer. Its mechanism of action is physical: it increases the viscosity of aqueous solutions, providing a thickening and stabilizing effect. It is used as a gelling agent and a suspending agent.
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|---|---|
| ln Vitro |
The resultant nanohybrid proved suited for application in aqueous solutions because hydroxyethyl cellulose was utilized to stabilize graphene oxide in physiological fluids. Graphene oxide can be efficiently stabilized in solution by hydroxyethyl cellulose, and the stabilization mechanism appears to be dependent on the amount of hydroxyethyl cellulose present. The hybrid's hydroxyethylcellulose content is crucial to the end use, serving as either the main drug carrier for folic acid or a vehicle for controlled drug release [1]. During the freeze-thaw process, hydroxyethylcellulose demonstrates remarkable cryoprotection against lactose diphosphate (LDH) and significant freeze-drying protection. There is not much of an impact of freezing on hydroxyethylcellulose stability. Tween 80, a surfactant, can be added to the formulation prior to freeze-drying in order to significantly increase the longer reconstitution time of hydroxyethylcellulose cellulose lyophilisate [2].
In vitro, Hydroxyethyl cellulose is characterized by its rheological properties. It is used to increase the viscosity of solutions and to stabilize proteins and enzymes. It is also used to suspend particles in formulations. Its activity is measured by its ability to increase the viscosity of aqueous solutions, which is determined using a viscometer. |
| ln Vivo |
In vivo, Hydroxyethyl cellulose is not used as a therapeutic agent. It is used as an excipient in pharmaceutical formulations, such as topical gels, ophthalmic solutions, and oral suspensions. It functions as a thickening agent and a stabilizer, improving the texture and consistency of the product.
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| Enzyme Assay |
The in vitro assay for Hydroxyethyl cellulose is not a biological assay but a physicochemical one. Its viscosity is measured using a viscometer at a specific temperature and concentration. Its purity and degree of substitution are determined by HPLC or other analytical methods. Its ability to form gels is assessed by measuring its rheological properties.
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| Cell Assay |
In vitro cell culture studies are not typically performed with Hydroxyethyl cellulose. However, its biocompatibility can be assessed by culturing cells on hydroxyethyl cellulose-based hydrogels and measuring cell viability and proliferation. Its use as a drug delivery vehicle can also be studied in cell-based models.
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| Animal Protocol |
In vivo animal experiments for Hydroxyethyl cellulose are not common for therapeutic testing. However, its safety and biocompatibility can be assessed in animal models. It is often used as a vehicle or suspending agent for the administration of test compounds in pharmacokinetic studies. It may also be used in wound healing models as a component of a hydrogel dressing.
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| ADME/Pharmacokinetics |
Hydroxyethyl cellulose is a solid powder with a molecular weight that varies depending on the degree of polymerization. It is soluble in hot and cold water, forming a clear, viscous solution. It is typically stored at room temperature in a dry place. Its stability is maintained under recommended storage conditions.
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| Toxicity/Toxicokinetics |
Toxicological data for Hydroxyethyl cellulose indicate that it is non-toxic and generally recognized as safe (GRAS). It is not absorbed from the gastrointestinal tract and does not cause systemic toxicity. It is not intended for therapeutic use and is classified as a food additive and pharmaceutical excipient.
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| References |
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| Additional Infomation |
Hydroxyethyl cellulose (HEC) is a polysaccharide derivative with gel-thickening, emulsifying, foaming, water-retaining, and stabilizing properties. Due to its nonionic and water-soluble nature, it is used as a key ingredient in many household cleaning products, lubricants, and cosmetics. It is commonly used as a component in ophthalmic drug formulations (such as artificial tears) and as an adjuvant in topical medications to facilitate the delivery of hydrophobic drugs. Drug Indications: For the relief of surface irritation caused by topical ocular administration (such as artificial tears). HEC is also present in topical formulations to help drugs diffuse more effectively across cell membranes. Mechanism of Action: Through hydrogen bonding with solid surfaces, it thickens and prolongs the formation time of the water-retaining film. As a drug carrier or microsphere, HEC can encapsulate other drug molecules and form a viscous gel-like dispersion, enabling the drug to diffuse across biological membranes. Pharmacodynamics: HEC can act as a lubricant to relieve ocular inflammation, irritation, and dryness. It is one of the key ingredients and also a thickener, which can prolong corneal contact time and increase intraocular drug concentration.
Hydroxyethyl cellulose is approved as a food additive and pharmaceutical excipient in many countries. It is widely used as a thickener, stabilizer, and film-former in various applications. It is used in cosmetics (e.g., shampoos, lotions), pharmaceuticals (e.g., gels, ophthalmic solutions), and in the food industry. It is not approved as a therapeutic drug. |
| Molecular Formula |
C29H52O21
|
|---|---|
| Molecular Weight |
736.7106
|
| Exact Mass |
154.012
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| CAS # |
9004-62-0
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| Related CAS # |
Cellulose;9004-34-6;CM Cellulose CM-32;9000-11-7
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| PubChem CID |
24846132
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| Appearance |
White to off-white solid powder
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| Density |
0.75 g/mL at 25ºC(lit.)
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| Melting Point |
288-290ºC (dec.)
|
| LogP |
0.352
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| Hydrogen Bond Donor Count |
11
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| Hydrogen Bond Acceptor Count |
21
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
50
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| Complexity |
999
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
CWSZBVAUYPTXTG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C29H52O21/c1-10-15(34)16(35)24(13(8-33)45-10)49-28-20(39)18(37)25(50-29-26(43-5-4-30)21(40)23(42-3)12(7-32)47-29)14(48-28)9-44-27-19(38)17(36)22(41-2)11(6-31)46-27/h10-40H,4-9H2,1-3H3
|
| Chemical Name |
5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~9.09 mg/mL
DMSO : ~1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3574 mL | 6.7869 mL | 13.5739 mL | |
| 5 mM | 0.2715 mL | 1.3574 mL | 2.7148 mL | |
| 10 mM | 0.1357 mL | 0.6787 mL | 1.3574 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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