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| Other Sizes |
| Targets |
Trisodium phosphate dodecahydrate does not have a defined biological target as a therapeutic agent. It is an inorganic salt used as a food additive, buffering agent, and pharmaceutical excipient. The compound is not intended to exert pharmacological effects. Its utility lies in its chemical properties as a source of phosphate ions and as a buffering agent.
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|---|---|
| ln Vitro |
Specific in vitro activity data for Trisodium phosphate dodecahydrate as a pharmacological agent are not documented in the literature. It is primarily used as a food additive and buffering agent. The compound is not characterized for direct biological activities such as enzyme inhibition or receptor modulation. Its effects in biological systems are related to its phosphate content and buffering capacity.
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| ln Vivo |
Trisodium phosphate dodecahydrate is not used for in vivo pharmacological activity assessment as a drug compound. It is a food additive, buffering agent, and pharmaceutical excipient. The compound is not intended to be administered for therapeutic purposes. Its safety has been evaluated in the context of its use as a food additive and pharmaceutical excipient.
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| Enzyme Assay |
Trisodium phosphate dodecahydrate is not typically used in enzyme/receptor binding assays as a test compound. Its primary applications are as a food additive and buffering agent. When used in research, it may be employed as a buffering agent in biochemical assays or as a standard for phosphate analysis.
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| Cell Assay |
The compound is not used in cell-based assays as a test compound. Its primary applications are as a food additive and buffering agent. It may be used as a component of cell culture media or buffers, but it is not characterized as a pharmacological agent for direct cellular effects.
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| Animal Protocol |
Trisodium phosphate dodecahydrate is not used in animal studies as a pharmacological agent. It may be used in nutritional studies or as a component of animal diets. Its safety has been evaluated in the context of its use as a food additive. It is not administered as a test compound for efficacy evaluations.
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| ADME/Pharmacokinetics |
Trisodium phosphate dodecahydrate has a molecular weight of 380.12 g/mol and a molecular formula of Na₃PO₄·12H₂O. It is a white crystalline solid that is highly soluble in water. The compound is used as a food additive, buffering agent, water softener, and cleaning agent. It is typically stored under standard laboratory conditions.
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| Toxicity/Toxicokinetics |
Trisodium phosphate dodecahydrate is approved as a food additive (E339) and is generally recognized as safe (GRAS) when used in accordance with established guidelines. It is not intended for human therapeutic use as a drug substance. As a research chemical, standard safety precautions should be observed when handling this compound, including the use of appropriate personal protective equipment.
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| References | |
| Additional Infomation |
See also: phosphate ion (with active portion).
The compound is not a drug and is an inorganic salt used as a food additive and buffering agent. |
| Molecular Formula |
H24NA36O16P
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|---|---|
| Molecular Weight |
380.18
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| Exact Mass |
380.049
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| CAS # |
10101-89-0
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| Related CAS # |
7601-54-9 (Parent);7632-05-5 (Parent)
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| PubChem CID |
61473
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| Appearance |
White to off-white solid powder
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| Density |
1.62
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| Boiling Point |
158ºC at 760 mmHg
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| Melting Point |
Melting point equals 164 to 170 ° F
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| Index of Refraction |
1.4458
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| Hydrogen Bond Donor Count |
12
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| Hydrogen Bond Acceptor Count |
16
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
20
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| Complexity |
36.8
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| Defined Atom Stereocenter Count |
0
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| SMILES |
P(=O)([O-])([O-])[O-].[Na+].[Na+].[Na+].O([H])[H].O([H])[H].O([H])[H].O([H])[H].O([H])[H].O([H])[H].O([H])[H].O([H])[H].O([H])[H].O([H])[H].O([H])[H].O([H])[H]
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| InChi Key |
ASTWEMOBIXQPPV-UHFFFAOYSA-K
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| InChi Code |
InChI=1S/3Na.H3O4P.12H2O/c;;;1-5(2,3)4;;;;;;;;;;;;/h;;;(H3,1,2,3,4);12*1H2/q3*+1;;;;;;;;;;;;;/p-3
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| Chemical Name |
trisodium;phosphate;dodecahydrate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6303 mL | 13.1517 mL | 26.3033 mL | |
| 5 mM | 0.5261 mL | 2.6303 mL | 5.2607 mL | |
| 10 mM | 0.2630 mL | 1.3152 mL | 2.6303 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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