| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| Other Sizes |
| Targets |
Laricitrin 3-O-glucoside exerts its biological effects through its flavonol scaffold. As a flavonoid, it acts as an antioxidant by scavenging free radicals and chelating metal ions. The compound may also exhibit anti-inflammatory and other biological activities through modulation of signaling pathways. Its presence in grapevine and spruce suggests potential roles in plant defense and human health benefits associated with flavonoid consumption.
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| ln Vitro |
In vitro, Laricitrin 3-O-glucoside has antioxidant properties. Its antioxidant activity is measured by its ability to scavenge free radicals in assays such as DPPH, ABTS, or ORAC. The compound reduces oxidative stress in cellular systems. As a flavonol glycoside, it may also exhibit anti-inflammatory and other biological activities. However, specific in vitro activity data for Laricitrin 3-O-glucoside are limited.
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| ln Vivo |
In vivo, Laricitrin 3-O-glucoside has not been extensively studied as a therapeutic agent. As a natural flavonoid found in grapes and spruce, it may contribute to the health benefits associated with consumption of these plants. However, specific in vivo data for the pure compound are lacking. The compound is primarily used as a research tool for studying flavonoid biology.
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| Enzyme Assay |
Non-cell-based assays for Laricitrin 3-O-glucoside involve characterization of its chemical properties and antioxidant activity. The compound's structure is confirmed by NMR and MS. Its purity is determined by HPLC. Antioxidant activity is assessed by DPPH radical scavenging assays, ABTS assays, or ORAC assays. The compound's solubility and stability are characterized for research applications.
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| Cell Assay |
Cellular assays for Laricitrin 3-O-glucoside are performed using various cell lines. Cells are treated with the compound at various concentrations, and cellular responses are measured. Cell viability is measured by MTT assays. Antioxidant activity is assessed by measuring intracellular ROS levels, glutathione levels, and antioxidant enzyme activities. Anti-inflammatory activity may be evaluated by measuring pro-inflammatory cytokine production.
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| Animal Protocol |
In vivo experiments with Laricitrin 3-O-glucoside are limited as the compound is primarily used as a research tool. Animal studies may involve administration of the compound to evaluate its antioxidant or other biological effects. However, detailed in vivo data are not available. The compound is for research use only and is not intended for human consumption.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Laricitrin 3-O-glucoside have not been extensively characterized. As a flavonol glycoside with a molecular weight of 494.4, the compound is expected to have moderate oral bioavailability. Its absorption, distribution, metabolism, and excretion are not well-defined. Flavonoid glycosides are typically metabolized in the gut by microbiota before absorption. Comprehensive PK studies are needed.
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| Toxicity/Toxicokinetics |
The toxicity profile of Laricitrin 3-O-glucoside has not been comprehensively evaluated. As a natural flavonoid found in foods, the compound is generally considered to be safe and well-tolerated. However, comprehensive toxicological studies including genotoxicity, organ toxicity, and maximum tolerated dose have not been fully characterized. The compound is for research use only.
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| References | |
| Additional Infomation |
It has been reported that European spruce and grapes contain larchin 3-O-glucoside, and there is relevant data available.
Laricitrin 3-O-glucoside (CAS# 39986-90-8) is a natural flavonoid compound with the molecular formula C₂₂H₂₂O₁₃ and a molecular weight of 494.4. It is also known as 3'-Methylmyricetin 3-glucoside and Laricitrin 3-glucoside. The compound is found in Picea abies (Norway spruce) and Vitis vinifera (grapevine) and has antioxidant properties. As of current knowledge, Laricitrin 3-O-glucoside is not approved as a therapeutic agent. |
| Molecular Formula |
C22H22O13
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|---|---|
| Molecular Weight |
494.402
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| Exact Mass |
494.106
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| CAS # |
39986-90-8
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| PubChem CID |
101682256
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
0.3
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| Hydrogen Bond Donor Count |
8
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| Hydrogen Bond Acceptor Count |
13
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
35
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| Complexity |
804
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| Defined Atom Stereocenter Count |
5
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| SMILES |
COC1=CC(=CC(=C1O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
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| InChi Key |
ODXINVOINFDDDD-CLXWZIMCSA-N
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| InChi Code |
InChI=1S/C22H22O13/c1-32-12-3-7(2-10(26)15(12)27)20-21(17(29)14-9(25)4-8(24)5-11(14)33-20)35-22-19(31)18(30)16(28)13(6-23)34-22/h2-5,13,16,18-19,22-28,30-31H,6H2,1H3/t13-,16-,18+,19-,22+/m1/s1
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| Chemical Name |
2-(3,4-dihydroxy-5-methoxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0227 mL | 10.1133 mL | 20.2265 mL | |
| 5 mM | 0.4045 mL | 2.0227 mL | 4.0453 mL | |
| 10 mM | 0.2023 mL | 1.0113 mL | 2.0227 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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