| Size | Price | Stock | Qty |
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| 1mg |
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| Other Sizes |
| Targets |
Quercetin 5,3′-dimethyl ether has anti-inflammatory and antibacterial activities. Its anti-inflammatory activity may be mediated through modulation of inflammatory signaling pathways such as NF-κB or MAPK. Its antibacterial activity suggests interactions with bacterial cellular components. As a flavonoid, it may also have antioxidant properties. However, specific molecular targets are not fully characterized in the available literature.
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| ln Vitro |
In vitro, Quercetin 5,3′-dimethyl ether has anti-inflammatory activity and antibacterial activity. Specific IC50 values or detailed mechanistic data are not extensively reported. As a flavonoid, it may also exhibit antioxidant activity. The compound is used in research on inflammation and bacterial infections. Further studies are needed to fully characterize its in vitro activity profile.
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| ln Vivo |
Specific in vivo data for Quercetin 5,3′-dimethyl ether are not reported. Given its anti-inflammatory and antibacterial activities, the compound has potential for in vivo studies in models of inflammation and bacterial infections. However, specific published in vivo protocols for this compound are not available. Further studies are needed to evaluate its in vivo efficacy and pharmacokinetic properties.
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| Enzyme Assay |
The anti-inflammatory activity is assessed using standard in vitro assays. Immune cells such as macrophages are treated with Quercetin 5,3′-dimethyl ether and stimulated with LPS or other inflammatory stimuli. Cytokine levels (TNF-α, IL-6, IL-1β) are measured by ELISA. Antibacterial activity is assessed using broth microdilution assays following CLSI guidelines. The compound has a molecular formula of C₁₇H₁₄O₇ and a molecular weight of 330.29 g/mol.
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| Cell Assay |
For cellular studies, immune cells (e.g., macrophages, monocytes) and bacterial cultures are used. Cells are cultured in appropriate media and treated with Quercetin 5,3′-dimethyl ether at various concentrations for 24-72 hours. Cytokine levels are measured by ELISA. For antibacterial testing, bacterial strains are cultured in broth media and treated with the compound, with growth monitored by optical density. The compound has a molecular formula of C₁₇H₁₄O₇ and a molecular weight of 330.29 g/mol.
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| Animal Protocol |
In vivo studies for Quercetin 5,3′-dimethyl ether would be conducted in appropriate animal models. For anti-inflammatory studies, models such as carrageenan-induced paw edema or LPS-induced systemic inflammation would be used. For antibacterial studies, infection models using relevant bacterial strains would be employed. The compound would be administered via oral gavage or intraperitoneal injection. However, specific published protocols are not available.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Quercetin 5,3′-dimethyl ether are not reported. The compound has a molecular formula of C₁₇H₁₄O₇ and a molecular weight of 330.29 g/mol. As a flavonoid, it is expected to have variable oral bioavailability due to extensive metabolism. Pharmacokinetic studies would be required to determine parameters such as absorption, distribution, metabolism, and excretion.
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| Toxicity/Toxicokinetics |
Toxicological data for Quercetin 5,3′-dimethyl ether are not reported. As a flavonoid compound, it is generally considered to have a moderate safety profile based on the known safety of dietary flavonoids. However, comprehensive toxicology studies have not been published. The compound should be handled with appropriate safety precautions.
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| References | |
| Additional Infomation |
Reports indicate that narrow-leaved heliotrope contains quercetin 5,3'-dimethyl ether, and relevant data is available for reference.
Quercetin 5,3′-dimethyl ether is a flavonoid from Combretum erythrophyllum with anti-inflammatory and antibacterial activities. Molecular formula: C₁₇H₁₄O₇, molecular weight: 330.29. No clinical trials exist. For research use only. |
| Molecular Formula |
C17H14O7
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|---|---|
| Molecular Weight |
330.29
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| Exact Mass |
330.074
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| CAS # |
40554-94-7
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| PubChem CID |
14162696
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
2.594
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
24
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| Complexity |
517
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COc1cc(ccc1O)-c1oc2cc(O)cc(OC)c2c(=O)c1O
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| InChi Key |
NKJWZTPASPJYBA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H14O7/c1-22-11-5-8(3-4-10(11)19)17-16(21)15(20)14-12(23-2)6-9(18)7-13(14)24-17/h3-7,18-19,21H,1-2H3
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| Chemical Name |
3,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-methoxychromen-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0276 mL | 15.1382 mL | 30.2764 mL | |
| 5 mM | 0.6055 mL | 3.0276 mL | 6.0553 mL | |
| 10 mM | 0.3028 mL | 1.5138 mL | 3.0276 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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