| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Gentianose does not have a specific biological target. As an oligosaccharide, it may serve as a prebiotic or be used in studies of carbohydrate metabolism. It is primarily a research chemical and natural product.
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|---|---|
| ln Vitro |
In vitro, Gentianose is a naturally occurring oligosaccharide. It may be used in studies of carbohydrate metabolism, enzyme specificity (e.g., glycosidases), or as a reference standard. No specific biological activities have been reported.
|
| ln Vivo |
In vivo, Gentianose is not used as a therapeutic agent. It is a research chemical. As an oligosaccharide, it may be fermented by gut microbiota if ingested. No specific pharmacological activities have been reported.
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| Enzyme Assay |
Cell-free assays for Gentianose involve its use as a substrate for glycosidase enzymes. The compound is incubated with glycosidases, and the release of monosaccharides is measured by reducing sugar assays or HPLC. It is used as a reference standard in carbohydrate analysis.
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| Cell Assay |
Cellular assays for Gentianose are not typical. As an oligosaccharide, it may be used in studies of cellular uptake or metabolism of carbohydrates. Cells are treated with Gentianose, and its effects on metabolism are assessed.
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| Animal Protocol |
In vivo animal studies for Gentianose have not been reported. As a research chemical, it is not used in therapeutic animal studies. No specific pharmacological studies have been described.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Gentianose are not extensively characterized. As an oligosaccharide, it is not absorbed intact and is fermented in the colon. Storage: typically at -20°C.
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| Toxicity/Toxicokinetics |
Comprehensive toxicity data for Gentianose are limited. As a naturally occurring oligosaccharide, it is generally considered safe at moderate doses. It is for research use only and not approved for clinical use.
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| References | |
| Additional Infomation |
Gentianose is a trisaccharide composed of β-D-glucopyranose, α-D-glucopyranose, and β-D-fructofuranose units. It is a plant metabolite. Gentianose has been reported to be found in plants of the Gentian genus (such as Gentiana and Gentiana macrophylla) and other organisms with relevant data.
Gentianose is a research compound used as a reference standard in carbohydrate analysis and in studies of glycosidase enzymes. It is a naturally occurring trisaccharide. The compound is available from chemical suppliers. No clinical applications have been reported. |
| Molecular Formula |
C18H32O16
|
|---|---|
| Molecular Weight |
504.44
|
| Exact Mass |
504.169
|
| CAS # |
25954-44-3
|
| PubChem CID |
117678
|
| Appearance |
White to off-white solid powder
|
| Density |
1.81g/cm3
|
| Boiling Point |
884.8ºC at 760 mmHg
|
| Melting Point |
208-210ºC
|
| Flash Point |
488.9ºC
|
| Vapour Pressure |
0mmHg at 25°C
|
| Index of Refraction |
1.676
|
| LogP |
-5.8
|
| Hydrogen Bond Donor Count |
11
|
| Hydrogen Bond Acceptor Count |
16
|
| Rotatable Bond Count |
8
|
| Heavy Atom Count |
34
|
| Complexity |
655
|
| Defined Atom Stereocenter Count |
14
|
| SMILES |
C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@H](O2)O[C@]3([C@H]([C@@H]([C@H](O3)CO)O)O)CO)O)O)O)O)O)O)O
|
| InChi Key |
MUPFEKGTMRGPLJ-WSCXOGSTSA-N
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| InChi Code |
InChI=1S/C18H32O16/c19-1-5-8(22)11(25)13(27)16(31-5)30-3-7-9(23)12(26)14(28)17(32-7)34-18(4-21)15(29)10(24)6(2-20)33-18/h5-17,19-29H,1-4H2/t5-,6-,7-,8-,9-,10-,11+,12+,13-,14-,15+,16-,17-,18+/m1/s1
|
| Chemical Name |
(2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6R)-6-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (198.24 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9824 mL | 9.9120 mL | 19.8240 mL | |
| 5 mM | 0.3965 mL | 1.9824 mL | 3.9648 mL | |
| 10 mM | 0.1982 mL | 0.9912 mL | 1.9824 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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