| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| Other Sizes |
| Targets |
Prenyletin shows anti-oxidative stress activity. It targets oxidative stress pathways. As a coumarin, it may also have other biological activities such as anti-inflammatory or antimicrobial effects. Its mechanism involves scavenging reactive oxygen species.
|
|---|---|
| ln Vitro |
In vitro, Prenyletin shows anti-oxidative stress activity. It is a natural product isolated from Ptaeroxylon obliquum. Detailed IC50 values are not reported. It may have antioxidant activity in cell-based or cell-free assays.
|
| ln Vivo |
In vivo, Prenyletin has potential applications in oxidative stress-related diseases based on its in vitro antioxidant activity. Animal studies are needed to confirm its in vivo efficacy and safety.
|
| Enzyme Assay |
Cell-free assays for Prenyletin involve antioxidant activity measurement. The compound is tested in DPPH, ABTS, or FRAP radical scavenging assays. It is incubated with radicals, and scavenging activity is measured spectrophotometrically. IC50 values are calculated from dose-response curves.
|
| Cell Assay |
Cellular assays for Prenyletin involve cells treated with the compound at concentrations of 0.1-100 µM for 24-72 hours. ROS levels are measured using DCFH-DA. Cell viability is assessed by MTT assay. Antioxidant enzyme activities (SOD, CAT, GPx) are measured in cell lysates.
|
| Animal Protocol |
In vivo animal studies for Prenyletin have not been extensively reported. Based on its antioxidant activity, animal models of oxidative stress could be used. Animals would be administered Prenyletin, and oxidative stress markers would be assessed.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of Prenyletin are not extensively characterized. Molecular weight: 246.26. Density: 1.237 g/cm3. Storage: typically at -20°C. Purity: ≥98%.
|
| Toxicity/Toxicokinetics |
Comprehensive toxicity data for Prenyletin are limited. As a natural coumarin, it is generally considered safe at moderate doses. It is for research use only and not approved for clinical use.
|
| References | |
| Additional Infomation |
It has been reported that angelica, Albizia julibrissin, and other organisms with available data contain isopentenyl groups...
Prenyletin is a research compound with potential applications in antioxidant and oxidative stress research. It is a prenylated coumarin from Ptaeroxylon obliquum. The compound is available from chemical suppliers. No clinical trials or FDA approvals have been reported. |
| Molecular Formula |
C14H14O4
|
|---|---|
| Molecular Weight |
246.26
|
| Exact Mass |
246.089
|
| CAS # |
15870-91-4
|
| PubChem CID |
3873459
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.237g/cm3
|
| Boiling Point |
451.6ºC at 760 mmHg
|
| Flash Point |
173.9ºC
|
| Vapour Pressure |
8.97E-09mmHg at 25°C
|
| Index of Refraction |
1.585
|
| LogP |
2.843
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
18
|
| Complexity |
368
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(=CCOC1=C(C=C2C=CC(=O)OC2=C1)O)C
|
| InChi Key |
AWEFUQDNSBBNCR-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C14H14O4/c1-9(2)5-6-17-13-8-12-10(7-11(13)15)3-4-14(16)18-12/h3-5,7-8,15H,6H2,1-2H3
|
| Chemical Name |
6-hydroxy-7-(3-methylbut-2-enoxy)chromen-2-one
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0607 mL | 20.3037 mL | 40.6075 mL | |
| 5 mM | 0.8121 mL | 4.0607 mL | 8.1215 mL | |
| 10 mM | 0.4061 mL | 2.0304 mL | 4.0607 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
