| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| Other Sizes |
| ln Vivo |
4-Chlorodiphenyl ether (10-150 mg/kg/day; subcutaneous injection; daily administration for 28 consecutive days) increased the survival rate of endometriotic cysts in ovariectomized B6C3F1 mice in a dose-dependent manner. The cyst survival rate in the 150 mg/kg/day group reached 60%, which was significantly higher than that in the solvent control group. In addition, the highest dose could alter the activity of hepatic microsomal enzymes [1]. 4-Chlorodiphenyl ether (68 nmol/kg; intravenous injection; single administration) was rapidly cleared from the blood, mainly accumulated in the liver, and was slowly cleared, with a systemic clearance rate of 4.05 mL·min−1·kg−1 [2].
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| Animal Protocol |
Animal/Disease Models:B6C3F1 (female, adult, 22-27 g, surgically induced endometriosis) [1]
Doses: 10 mg/kg/day; 75 mg/kg/day; 150 mg/kg/day Route of Administration: Subcutaneous injection; once daily for 28 days Experimental Results: The survival rate of endometriotic cysts reached 28%; there was no significant difference in cyst diameter compared with the solvent control group; there were no significant changes in liver BROD, MROD, EROD or PROD enzyme activities compared with the solvent control group. The survival rate of endometriotic cysts reached 36%; there was no significant difference in cyst diameter compared with the solvent control group; there were no significant changes in liver BROD, MROD, EROD or PROD enzyme activities compared with the solvent control group. The survival rate of endometriotic cysts reached 60% (significantly higher than the 8% in the vector control group); there was no significant difference in cyst diameter compared with the vector control group; compared with the vector control group, the estrone treatment group, and the 10/75 mg/kg/day 4-CDE group, liver BROD enzyme activity was significantly increased, and liver MROD enzyme activity was significantly decreased; liver EROD enzyme activity was significantly lower than that in the estrone treatment group; there was no significant change in liver PROD enzyme activity compared with the vector control group. |
| References |
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| Molecular Formula |
C12H9CLO
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|---|---|
| Molecular Weight |
204.65
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| CAS # |
7005-72-3
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| Related CAS # |
4-Chlorodiphenyl ether-d5
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| Appearance |
Liquid
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| SMILES |
ClC1=CC=C(OC=2C=CC=CC2)C=C1
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| Synonyms |
4-CDE
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8864 mL | 24.4320 mL | 48.8639 mL | |
| 5 mM | 0.9773 mL | 4.8864 mL | 9.7728 mL | |
| 10 mM | 0.4886 mL | 2.4432 mL | 4.8864 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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