| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vivo |
Lmiquimod (IMQ) can be used to induce a psoriasis model[5]. Induced psoriasis model[5] Pathogenic mechanism Lmiquimod (IMQ) can induce inflamed scaly skin lesions similar to plaque psoriasis. IMQ induces epidermal expression of IL-23, IL-17A and IL-17F, as well as an increase in splenic Th17 cells. Specific modeling method: Mice: BALB/c • Male • 8 weeks old Dosage method: 3.125 mg/day • Topical application to the skin • 6 days Note Modeling success indicators Histological changes: The induced mouse back skin begins to show signs of erythema, scaling and thickening. It causes excessive proliferation of keratinocytes and disrupts epidermal differentiation (parakeratosis). Related products: / Antagonist products: /
|
|---|---|
| References |
| Molecular Formula |
C14H18CL2N4
|
|---|---|
| Molecular Weight |
313.23
|
| CAS # |
2995277-02-4
|
| Related CAS # |
Imiquimod;99011-02-6
|
| Synonyms |
R 837 dihydrochloride
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1925 mL | 15.9627 mL | 31.9254 mL | |
| 5 mM | 0.6385 mL | 3.1925 mL | 6.3851 mL | |
| 10 mM | 0.3193 mL | 1.5963 mL | 3.1925 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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