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CPD-002

Cat No.:V103933 Purity: ≥98%
CPD-002
CPD-002 Chemical Structure CAS No.: 2617376-08-4
Product category: VEGFR
This product is for research use only, not for human use. We do not sell to patients.
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500mg
1g
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Product Description
CPD-002 is an inhibitor of vascular endothelial growth factor receptor 2 (VEGFR 2), which inhibits angiogenesis by inhibiting the VEGFR2/PI3K/AKT signaling pathway. CPD-002 has anti-inflammatory activity and can alleviate rheumatoid arthritis.
Biological Activity I Assay Protocols (From Reference)
ln Vitro
CPD-002 (0-64 μM, 24-48 h) is cytotoxic to HUVEC and MH7A cells in a dose-dependent manner [1]. CPD-002 (0-8 μM, 24 h) inhibits VEGF-induced HUVEC cell migration and invasion by suppressing F-actin expression and chemotactic response to chemoattractants released by MH7A cells [1]. CPD-002 (0-8 μM) exerts anti-inflammatory activity by inhibiting inflammatory mediators such as TNF-α, IL-1β, IL-6, IL-8, MMP2, and MMP9, thereby inhibiting synovial angiogenesis[1]. CPD-002 (0-8 μM, 9 days) inhibits HUVEC tube formation and aortic ring sprout formation in an isolated rat aortic ring assay [1].
ln Vivo
CPD-002 (15-60 mg/kg, intraperitoneally, once daily for 14 days) exhibits anti-arthritic and anti-angiogenic activities in an adjuvant-induced arthritis rat model [1].
Cell Assay
Cell Viability Assay[1]
Cell Types: HUVECs and MH7A Tested
Tested Concentrations: 0-64 μM
Incubation Duration: 24-48 h
Experimental Results: Inhibited cell viability in a dose-dependent manner. Cell Migration Assay [1]
Cell Types: HUVECs Tested
Tested Concentrations: 0-8 μM
Incubation Duration: 24 h
Experimental Results: Inhibited HUVECs migration in a dose-dependent manner.
Animal Protocol
Animal/Disease Models: adjuvant-induced arthritis (AIA) Sprague Dawley rats models[1]
Doses: 15-60 mg/kg
Route of Administration: i.p., once daily for 14 days
Experimental Results: Ameliorated paw swelling, joint damage, and synovial angiogenesis.
References

[1]. CPD-002, a novel VEGFR2 inhibitor, relieves rheumatoid arthritis by reducing angiogenesis through the suppression of the VEGFR2/PI3K/AKT signaling pathway. Int Immunopharmacol. 2024 Apr 20;131:111850.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C17H16N4O2S
Molecular Weight
340.40
CAS #
2617376-08-4
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.9377 mL 14.6886 mL 29.3772 mL
5 mM 0.5875 mL 2.9377 mL 5.8754 mL
10 mM 0.2938 mL 1.4689 mL 2.9377 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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