| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| Targets |
5-HT1A Receptor 5-HT2A Receptor
|
|---|---|
| ln Vitro |
1-1-Naphthylpiperazine hydrochloride (50-300 μM) inhibits melanoma MNT-1 cells by arresting the cell cycle at S phase, inducing apoptosis and ROS production with an IC50 of 163.6 μM[1]. 1-1-Naphthylpiperazine hydrochloride (0-200 μM) can regulate the expression of genes related to UV-induced immunosuppression[1].
|
| ln Vivo |
1-1-Naphthylpiperazine hydrochloride (1 μM, ip, single dose) promotes UV radiation-induced DNA repair via the nucleotide excision repair (NER) mechanism, thereby preventing immunosuppression and interfering with photocarcinogenesis in UVB-exposed C57BL/6 mice [2].
|
| Cell Assay |
Cell Viability Assay[1]
Cell Types: MNT-1 Tested Tested Concentrations: 50-300 μM Incubation Duration: 3-24 h Experimental Results: Inhibited cell viability RT-PCR[1] Cell Types: MNT-1 Tested Tested Concentrations: 0-150 μM Incubation Duration: 24 h Experimental Results: Downregulated levels of PAK1, upregulated levels of PTGS2 and IL12A. |
| Animal Protocol |
Animal/Disease Models: UVB-radiation exposed C57BL/6 mice and XPA-/- mice[2]
Doses: 1 μM Route of Administration: i.p., single dose Experimental Results: Accelerated the repair of UV-induced photoproducts with presence of NER. |
| References |
| Molecular Formula |
C14H17CLN2
|
|---|---|
| Molecular Weight |
248.75
|
| CAS # |
104113-71-5
|
| SMILES |
Cl.N1CCN(C2=CC=CC3=CC=CC=C23)CC1
|
| Synonyms |
1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0201 mL | 20.1005 mL | 40.2010 mL | |
| 5 mM | 0.8040 mL | 4.0201 mL | 8.0402 mL | |
| 10 mM | 0.4020 mL | 2.0101 mL | 4.0201 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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