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    Nicotinamide (Vitamin B3)
    Nicotinamide (Vitamin B3)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0432
    CAS #: 98-92-0Purity ≥98%

    Description: Nicotinamide (Vitamin B3; Niacinamide; Nicotinic acid amide), a water-soluble and active form of vitamin B3, is a potent and active component of coenzymes NAD and NADP. It is commonly used as a dietary supplement and medication. As a supplement, it is used by oral administration to prevent and treat pellagra. Nicotinamide also act as an inhibitor of sirtuins. Nicotinamide is also an inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. Poly(ADP-ribose) polymerase-1 (PARP-1) is found as a DNA repair enzyme. The excessive activation of PARP-1, such as ischemia and trauma, can deplete cellular nicotinamide adenine dinucleotide as a substrate and leads to brain cell death eventually.

    References: J Biol Chem. 2002 Nov 22;277(47):45099-107.

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    Molecular Weight (MW)122.12
    FormulaC6H6N2O
    CAS No.98-92-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 24 mg/mL (196.52 mM)  
    Water: 24 mg/mL (196.52 mM)
    Ethanol: 24 mg/mL (196.52 mM)
    Other info

    Chemical Name: 3-Pyridinecarboxylic acid amide

    InChi Key: DFPAKSUCGFBDDF-UHFFFAOYSA-N

    InChi Code: InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

    SMILES Code: O=C(C1=CC=CN=C1)N

    SynonymsNiacinamide, Vitamin PP, Nicotinic acid amide; Vitamin B3



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    In Vitro

    In vitro activity: Nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and shortens replicative life span to that of a sir2 mutant. Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G(1)-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity. Nicotinamide results in a twofold increase in DNA content and a threefold increase in insulin content in the fetal cells. Nicotinamide induces differentiation and maturation of human fetal pancreatic islet cells. Nicotinamide regulates sirtuins by switching between deacetylation and base exchange. Nicotinamide switching is quantitated for the Sir2s from Archeaglobus fulgidus (Sir2Af2), Saccharomyces cerevisiae (Sir2p), and mouse (Sir2alpha). Nicotinamide selectively reduces a specific phospho-species of tau (Thr231) that is associated with microtubule depolymerization in Alzheimer's disease transgenic mice, in a manner similar to inhibition of SirT1. Nicotinamide also dramatically increases acetylated alpha-tubulin, a primary substrate of SirT2, and MAP2c in Alzheimer's disease transgenic mice, both of which are linked to increased microtubule stability. Nicotinamide fosters DNA integrity and maintains phosphatidylserine membrane asymmetry to prevent cellular inflammation, cellular phagocytosis and vascular thrombosis. Nicotinamide both prevents and reverses neuronal and vascular cell injury.


    Cell Assay: Previous findings suggested that nicotinamide had a protective effect against PARP-1-induced astrocyte death. The transporter-mediated uptake of nicotinamide, which was extracellular pH-sensitive and common to N-methylnicotinamide, was found to be critical for prevention of PARP-1-triggered cell death.

    In VivoType 2 diabetes was induced in Wistar rats by streptozotocin followed by nicotinamide. Test compounds and standard treatment were continued for 15 days. Results showed that there was significant normalisation of liver antioxidant enzymes compared to diabetic rats, suggesting all the tested compounds were beneficial in reducing oxidative stress 
    Animal modelRats and Mice: Normal and streptozotocin-nicotinamide induced adult male diabetic rats receive quercetin (10, 25 and 50 mg/kg/bw) orally, and cause significant decrease in FBG and cardiac injury marker levels with increased in insulin levels[2]. Nicotinamide improves maternal hypertension, proteinuria, and glomerular endotheliosis in RUPP mice. Moreover, nicotinamide prolongs pregnancies, and improves survival and growth of the embryos in RUPP PE mice
    Formulation & Dosage10, 25 and 50 mg/kg; oral
    References

    J Biol Chem. 2002 Nov 22;277(47):45099-107; ScientificWorldJournal. 2014;2014:854267; Life Sci. 2010 Apr 24;86(17-18):676-82.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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