| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
||
| 1g |
|
||
| 2g |
|
||
| 5g |
|
||
| 10g |
|
||
| 25g |
|
||
| Other Sizes |
|
Purity: ≥98%
Lipoic Acid, formerly known as R-(+)-alpha-Lipoic acid, is an organosulfur compound derived from octanoic acid. It is necessary for aerobic metabolism and is normally produced by animals. In certain countries, it is marketed as an antioxidant and is produced for use as a dietary supplement. In other countries, it is sold as a pharmaceutical drug.
| Molecular Formula |
C8H14O2S2
|
|---|---|
| Molecular Weight |
206.3256
|
| Exact Mass |
206.04
|
| Elemental Analysis |
C, 46.57; H, 6.84; O, 15.51; S, 31.08
|
| CAS # |
1200-22-2
|
| Related CAS # |
Lipoic acid; 1200-22-2
|
| Appearance |
Light yellow to dark brown solid powder
|
| SMILES |
C1CSS[C@@H]1CCCCC(=O)O
|
| InChi Key |
AGBQKNBQESQNJD-SSDOTTSWSA-N
|
| InChi Code |
InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
|
| Chemical Name |
5-[(3R)-dithiolan-3-yl]pentanoic acid
|
| Synonyms |
Thiogamma oral; R-(+)-alpha-Lipoic acid; (+)-alpha-Lipoic acid; Lipoate;Verla Lipon; Verla-Lipon; VerlaLipon; Lipoic Acid; Thioctacide T; Thioctic Acid; (R)-5-(1,2-Dithiolan-3-yl)pentanoic acid; Thiogamma Injekt; thioctic acid;
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ≥ 100 mg/mL (~484.7 mM)
H2O: ~1 mg/mL (~4.9 mM) |
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8466 mL | 24.2330 mL | 48.4660 mL | |
| 5 mM | 0.9693 mL | 4.8466 mL | 9.6932 mL | |
| 10 mM | 0.4847 mL | 2.4233 mL | 4.8466 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT03161028 | Active Recruiting |
Drug: Lipoic acid Drug: Placebo |
Multiple Sclerosis | VA Office of Research and Development |
July 1, 2018 | Phase 2 |
| NCT00765310 | Active Recruiting |
Dietary Supplement: Placebo Dietary Supplement: R-alpha lipoic acid |
Atherosclerosis | Oregon State University | April 2009 | Phase 2 Phase 3 |
| NCT00764270 | Active Recruiting |
Dietary Supplement: R-alpha lipoic acid |
Atherosclerosis | Oregon State University | August 2011 | Phase 2 Phase 3 |
| NCT02910531 | Active Recruiting |
Drug: Placebo Dietary Supplement: Alpha lipoic acid |
Cystinuria | Thomas Chi, MD | June 19, 2017 | Phase 2 |
| NCT06131918 | Active Recruiting |
Drug: Resveratrol Drug: Alpha lipoic acid |
Multiple Sclerosis | Khyber Medical University Peshawar | January 9, 2023 | Phase 2 |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA