| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Phospholipid biosynthesis. Iprobenfos acts as a phospholipid biosynthesis inhibitor, which is the basis for its antifungal activity. The compound is an organic thiophosphate that functions as a rice fungicide. Its mechanism of action involves disruption of fungal cell membrane synthesis.
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|---|---|
| ln Vitro |
Iprobenfos exerts its antifungal activity by inhibiting phospholipid biosynthesis, disrupting fungal cell membrane synthesis and function. The compound is highly effective against rice blast (leaf and ear blast), stem rot, and sheath blight. It is a low-toxicity organophosphorus fungicide.
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| ln Vivo |
In vivo, iprobenfos is used as a rice fungicide to control leaf and ear blast, stem rot, and sheath blight. It is applied at a rate of approximately 150g per mu, diluted 300-600 times, with a control efficacy of about 85%. The compound is a highly effective, low-toxicity organophosphorus fungicide.
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| Enzyme Assay |
In vitro antifungal assays for iprobenfos involve measuring its inhibitory effects on fungal growth. Fungal pathogens (such as Magnaporthe grisea) are cultured in the presence of various concentrations of iprobenfos. Fungal growth is measured by colony diameter or biomass. IC50 values are determined from concentration-response curves.
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| Cell Assay |
There are no reported in vitro cellular assays for iprobenfos as a therapeutic agent. The compound is used as an agricultural fungicide. Cellular studies may be conducted to assess the compound's effects on fungal cells or its toxicity to non-target organisms, but these are not therapeutic assays.
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| Animal Protocol |
In vivo animal studies for iprobenfos are primarily conducted in the context of agricultural efficacy and toxicology. The compound is applied to rice plants to assess its efficacy against fungal diseases. Toxicological studies may be conducted in animals to assess safety for agricultural workers and consumers.
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| ADME/Pharmacokinetics |
Iprobenfos is a colorless transparent oily liquid with a boiling point of 126°C (5.3 Pa) and a refractive index of 1.5106. It is readily soluble in various organic solvents but poorly soluble in water (0.1% at 18°C). The compound is stable to light and acidic conditions but decomposes in alkaline media.
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| Toxicity/Toxicokinetics |
Iprobenfos is considered a low-toxicity organophosphorus fungicide. It should be handled with appropriate safety precautions. The compound is stable to light and acidic conditions but decomposes in alkaline media. Toxicological studies support its use in agriculture.
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| References |
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| Additional Infomation |
Propylenephos is an organothiophosphate, specifically the S-benzyl O,O-diisopropyl ester of thiophosphates. It is used as a fungicide for rice to control rice blast, panicle blast, stem rot, and sheath blight. It is also a phospholipid biosynthesis inhibitor and an antifungal pesticide.
Iprobenfos is an organic thiophosphate fungicide used primarily as a rice fungicide to control leaf and ear blast, stem rot, and sheath blight. It is the S-benzyl O,O-diisopropyl ester of phosphorothioic acid. The compound acts as a phospholipid biosynthesis inhibitor and is a highly effective, low-toxicity organophosphorus fungicide. It has a molecular formula of C13H21O3PS and a molecular weight of 288.34. |
| Molecular Formula |
C13H21O3PS
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|---|---|
| Molecular Weight |
288.34
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| Exact Mass |
288.094
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| Elemental Analysis |
C, 54.15; H, 7.34; O, 16.65; P, 10.74; S, 11.12
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| CAS # |
26087-47-8
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| PubChem CID |
33294
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| Appearance |
Solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
354.4±35.0 °C at 760 mmHg
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| Melting Point |
22.5-23.8ºC
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| Flash Point |
168.1±25.9 °C
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| Vapour Pressure |
0.0±0.8 mmHg at 25°C
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| Index of Refraction |
1.514
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| LogP |
3.21
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
18
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| Complexity |
261
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC(C)OP(=O)(OC(C)C)SCC1=CC=CC=C1
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| InChi Key |
FCOAHACKGGIURQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H21O3PS/c1-11(2)15-17(14,16-12(3)4)18-10-13-8-6-5-7-9-13/h5-9,11-12H,10H2,1-4H3
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| Chemical Name |
S-benzyl O,O-diisopropyl phosphorothioate
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| Synonyms |
Iprobenfos; Kitazin L; Kitazin P; Ricid P; Ricid II;
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| HS Tariff Code |
2934.99.03.00
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4681 mL | 17.3406 mL | 34.6813 mL | |
| 5 mM | 0.6936 mL | 3.4681 mL | 6.9363 mL | |
| 10 mM | 0.3468 mL | 1.7341 mL | 3.4681 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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