| Size | Price | Stock | Qty |
|---|---|---|---|
| 2mg |
|
||
| 5mg |
|
||
| 10mg |
|
||
| 25mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| Other Sizes |
|
Purity: ≥98%
GSK-LSD1 2HCl, the dihydrochloride salt of GSK-LSD1 (GSK-LSD-1), is an irreversible, potent and selective inhibitor of Lysine (K) -specific demethylase 1A (LSD1) with antineoplastic activity. It inhibits LSD1 with an IC50 of 16 nM, and shows > 1000 fold selectivity for LSD1 over other closely related FAD dependent enzymes such as LSD2, MAO-A, and MAO-B. It displays potent in vitro antiproliferative activity and high in vivo antitumor efficacy.
| ln Vitro |
|
||
|---|---|---|---|
| ln Vivo |
|
||
| Animal Protocol |
|
||
| References |
Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437.; http://www.thesgc.org/chemical-probes/LSD1.
|
| Molecular Formula |
C14H22CL2N2
|
|---|---|
| Molecular Weight |
289.243881702423
|
| CAS # |
1821798-25-7
|
| Related CAS # |
2102933-95-7 (rel-2HCl);1431367-49-5 (rel-HCl);1431368-48-7 (rel-free base);1821798-25-7 (2HCl);1431367-51-9 (HCl);1431368-50-1;
|
| SMILES |
[H]Cl.[H]Cl.C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1
|
| InChi Key |
PJFZOGMSPBHPNS-WICJZZOFSA-N
|
| InChi Code |
InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1
|
| Chemical Name |
rel- N-[(1R,2S)-2-Phenylcyclopropyl]-4-Piperidinamine hydrochloride (1:2)
|
| Synonyms |
GSK-LSD1 dihydrochloride; GSK-LSD1; GSK-LSD 1; GSK-LSD-1; GSK-LSD1 2HCl; GSK-LSD1 (trans-racemic) dihydrochloride; GSK-LSD1 HCl;
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
|
|---|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4573 mL | 17.2867 mL | 34.5734 mL | |
| 5 mM | 0.6915 mL | 3.4573 mL | 6.9147 mL | |
| 10 mM | 0.3457 mL | 1.7287 mL | 3.4573 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA