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    GNE-955
    GNE-955

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4558
    CAS #: 1527523-39-2Purity ≥98%

    Description: GNE-955 is a novel, potent and orally bioavailable pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively. Pim kinases have been identified as promising therapeutic targets for hematologic-oncology indications, including multiple myeloma and certain leukemia. GNE-955 was discovered bearing 5-azaindazole core with noncanonical hydrogen bonding to the hinge.

    References 2017 May 25;60(10):4458-4473.


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    GNE-955

    Name: GNE-955
    CAS#: 1527523-39-2
    Chemical Formula: C23H25N7O
    Exact Mass: 415.2121
    Molecular Weight: 415.501
    Elemental Analysis: C, 66.49; H, 6.06; N, 23.60; O, 3.85
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: GNE-955; GNE 955; GNE955.
    IUPAC/Chemical Name: (S)-1-(2-methoxy-5-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl)piperidin-3-amine
    InChi Key: ASRHSBIEFUFSJR-KRWDZBQOSA-N
    InChi Code: InChI=1S/C23H25N7O/c1-15-10-25-13-20(28-15)19-9-21-16(11-26-19)12-27-30(21)18-5-6-23(31-2)22(8-18)29-7-3-4-17(24)14-29/h5-6,8-13,17H,3-4,7,14,24H2,1-2H3/t17-/m0/s1
    SMILES Code: CC1=NC(C2=NC=C(C=NN3C4=CC=C(OC)C(N5CCC[[email protected]](N)C5)=C4)C3=C2)=CN=C1


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