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    GNE-8505
    GNE-8505

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4554
    CAS #: 1620573-48-9Purity ≥98%

    Description: GNE-8505 is a novel, potent and orally bioavailable inhibitor of Dual leucine zipper kinase (DLK). Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and neuronal cell death, yet the cellular pathways that underlie these processes remain largely undefined. Dual leucine zipper kinase (DLK) is an essential regulator of the progressive neurodegeneration that occurs in amyotrophic lateral sclerosis and Alzheimer's disease. DLK/c-Jun N-terminal kinase signaling was increased in mouse models and human patients with these disorders and that genetic deletion of DLK protected against axon degeneration, neuronal loss, and functional decline in vivo. Furthermore, pharmacological inhibition of DLK activity was sufficient to attenuate the neuronal stress response and to provide functional benefit even in the presence of ongoing disease. These findings demonstrate that pathological activation of DLK is a conserved mechanism that regulates neurodegeneration and suggest that DLK inhibition may be a potential approach to treat multiple neurodegenerative diseases.

    References:  2017 Aug 16;9(403). pii: eaag0394.


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    GNE-8505

    Molecular Weight: 419.44
    Formula: C₂₁H₂₄F₃N₅O
    CAS No.: 1620573-48-9
    SMILES: FC(F)(F)C1=CC(C2=NN(C([[email protected]@H]3[[email protected]]4([H])[[email protected]@]3([H])CN(C5COC5)C4)=C2)CC6CC6)=CN=C1N
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationGNE-8505; GNE 8505; GNE8505


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