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    GNE-220
    GNE-220

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4543
    CAS #: 1199590-75-4Purity ≥98%

    Description: GNE-220 is a novel, potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM. Cell migration is a stepwise process that coordinates multiple molecular machineries. Using in vitro angiogenesis screens with short interfering RNA and chemical inhibitors, we define here a MAP4K4-moesin-talin-β1-integrin molecular pathway that promotes efficient plasma membrane retraction during endothelial cell migration. Loss of MAP4K4 decreased membrane dynamics, slowed endothelial cell migration, and impaired angiogenesis in vitro and in vivo. In migrating endothelial cells, MAP4K4 phosphorylates moesin in retracting membranes at sites of focal adhesion disassembly. 

    ReferencesNature. 2015 Mar 26;519(7544):425-30.


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    GNE-220

    Molecular Weight: 438.53
    Formula: C₂₅H₂₆N₈
    CAS No.: 1199590-75-4
    SMILES: CN1N=CC(C2=NC(C)=C(NC3=NC=C(C4=CC=C(N5CCN(C)CC5)C=C4)C=C36)C6=N2)=C1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationGNE-220; GNE220; GNE 220


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