| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| References | |
|---|---|
| Additional Infomation |
NOV-002 is a lead compound that can be used in combination with chemotherapy drugs as a chemoprotective and immunomodulatory agent. NOV-002 has been approved by the Russian Federation and marketed by the Russian Federal Pharmaceutical Company BAM under the brand name Glutoxim. This drug has been used in over 10,000 patients with significant clinical efficacy and excellent safety data. NOV-002 is a stable disulfide glutathione formulation composed of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1), possessing potential chemoprotective and immunomodulatory activities. The glutathione disulfide NOV-002 mimics endogenous GSSG and, as a competitive substrate for gamma-glutamyl transferase (GGT), may lead to S-glutathionization of proteins (primarily actin), thereby inducing endoplasmic reticulum (ER) redox stress and ultimately resulting in ER stress-induced apoptosis. Glutathione disulfide (NOV-002)-induced GGT activity enhancement releases reactive oxygen species (ROS), which in turn stimulate S-glutathioneization. Furthermore, NOV-002 may also induce phosphorylation of proteins such as ERK and p38, two kinases that play crucial regulatory roles in cell proliferation and apoptosis. The cisplatin component of this drug does not provide effective therapeutic concentrations in vivo. Drug Indications It has been studied for the treatment of breast, lung, and ovarian cancer. Mechanism of Action NOV-002 inhibits tumor cell growth by stimulating the immune system through multiple pathways. Chemotherapy drugs, such as doxorubicin, cyclophosphamide, and docetaxel, inhibit tumor cell growth through different mechanisms, including killing tumor cells or preventing tumor cell division. Combination chemotherapy (multiple drugs) may kill more tumor cells. Preoperative combination chemotherapy with NOV-002 may shrink tumor volume and reduce the amount of normal tissue that needs to be removed.
|
| Molecular Formula |
C20H30N6O12S2-2.2[NA+]
|
|---|---|
| Molecular Weight |
656.5948
|
| Exact Mass |
656.115
|
| CAS # |
103239-24-3
|
| Related CAS # |
Glutathione oxidized;27025-41-8
|
| PubChem CID |
76967787
|
| Appearance |
Typically exists as solid at room temperature
|
| Hydrogen Bond Donor Count |
8
|
| Hydrogen Bond Acceptor Count |
16
|
| Rotatable Bond Count |
17
|
| Heavy Atom Count |
42
|
| Complexity |
857
|
| Defined Atom Stereocenter Count |
4
|
| SMILES |
O=C(O)CNC([C@@H](N=C([O-])CC[C@H](N)C(O)=O)CSSC[C@@H](C(NCC(O)=O)=O)N=C([O-])CC[C@H](N)C(O)=O)=O.[Na+].[Na+]
|
| InChi Key |
DRFILBXQKYDTFW-JIWRMXRASA-L
|
| InChi Code |
InChI=1S/C20H32N6O12S2.2Na/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38;;/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38);;/q;2*+1/p-2/t9-,10-,11-,12-;;/m0../s1
|
| Chemical Name |
disodium;(2S)-2-amino-5-[[(2R)-3-[[(2R)-2-[[(4S)-4-amino-4-carboxylatobutanoyl]amino]-3-(carboxylatomethylamino)-3-oxopropyl]disulfanyl]-1-(carboxylatomethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoate;hydron
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5230 mL | 7.6151 mL | 15.2302 mL | |
| 5 mM | 0.3046 mL | 1.5230 mL | 3.0460 mL | |
| 10 mM | 0.1523 mL | 0.7615 mL | 1.5230 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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