Size | Price | Stock | Qty |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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10g |
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Other Sizes |
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Purity: ≥98%
Foscarnet Sodium (also known as Phosphonoformate), an antiherpesvirus agent, inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. Foscarnet Sodium is able to penetrate into cells and inhibit viral replication by inhibiting viral DNA synthesis. Foscarnet Sodium (300 μM) displays a more than 95% inhibition on HTLV-III reverse transcriptase activity in H9 cells infected with HTLV-III. Foscarnet Sodium has a low cellular toxicity, but shows an inhibition of cell proliferation at high concentrations, which is reversed after drug removal.
ln Vitro |
Influenza A Victoria (IC50=29 μM), influenza B HK (IC50=61 μM), avian influenza myeloblastosis virus (IC50=5-8 μM), HSV-1, etc. strains (IC50=0.4-3.5 μM) are all inhibited by foscarnet sodium (Trisodium phosphonoformate)[2].
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ln Vivo |
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Animal Protocol |
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References |
[1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5.
[2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24. |
Molecular Formula |
CNA3O5P
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Molecular Weight |
191.95
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CAS # |
63585-09-1
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SMILES |
P(C(=O)[O-])(=O)([O-])[O-].[Na+].[Na+].[Na+]
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InChi Key |
DFHAXXVZCFXGOQ-UHFFFAOYSA-K
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InChi Code |
InChI=1S/CH3O5P.3Na/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/q;3*+1/p-3
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Chemical Name |
trisodium;phosphonatoformate
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.2097 mL | 26.0485 mL | 52.0969 mL | |
5 mM | 1.0419 mL | 5.2097 mL | 10.4194 mL | |
10 mM | 0.5210 mL | 2.6048 mL | 5.2097 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.