Foscarnet Sodium

Alias: Phosphonoformate;Trisodium phosphonoformate; Phosphonoformic acid trisodium salt
Cat No.:V1829 Purity: ≥98%
Foscarnet Sodium (also known as Phosphonoformate),an antiherpesvirus agent,inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
Foscarnet Sodium Chemical Structure CAS No.: 63585-09-1
Product category: Reverse Transcriptase
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
25mg
50mg
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Foscarnet Sodium (also known as Phosphonoformate), an antiherpesvirus agent, inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. Foscarnet Sodium is able to penetrate into cells and inhibit viral replication by inhibiting viral DNA synthesis. Foscarnet Sodium (300 μM) displays a more than 95% inhibition on HTLV-III reverse transcriptase activity in H9 cells infected with HTLV-III. Foscarnet Sodium has a low cellular toxicity, but shows an inhibition of cell proliferation at high concentrations, which is reversed after drug removal.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
Influenza A Victoria (IC50=29 μM), influenza B HK (IC50=61 μM), avian influenza myeloblastosis virus (IC50=5-8 μM), HSV-1, etc. strains (IC50=0.4-3.5 μM) are all inhibited by foscarnet sodium (Trisodium phosphonoformate)[2].
ln Vivo
Foscarnet Sodium display an efficient therapy effect on animal with virus diseases, such as cutaneous infection, herpes keratitis, genital infection, or systemic and interacerebral infection. For example, Foscarnet Sodium (100 mM) applied at initiated 48 h post inoculation with twice daily applications of 30 μL for 4 days, displays a more than 70% reduction in cumulative score after inoculation with HSV-1 strain C42. Foscarnet Sodium (20 mg/kg) given as an aerosol to mice infected with murine CMV caused a reduction of 60% in lung titers.
Animal Protocol
Dissolved in Water solution with 0.1% Tween 80 and 10% (wt/wt) glycerol and adjusted to pH 6.0; 5 mM; Topical application
Guinea-pigs with cutaneous HSV-1 infections on the backs
References
[1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5.
[2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415.
[3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
CNA3O5P
Molecular Weight
191.95
CAS #
63585-09-1
SMILES
P(C(=O)[O-])(=O)([O-])[O-].[Na+].[Na+].[Na+]
InChi Key
DFHAXXVZCFXGOQ-UHFFFAOYSA-K
InChi Code
InChI=1S/CH3O5P.3Na/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/q;3*+1/p-3
Chemical Name
trisodium;phosphonatoformate
Synonyms
Phosphonoformate;Trisodium phosphonoformate; Phosphonoformic acid trisodium salt
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO:7 mg/mL (36.5 mM)
Water:3 mg/mL (15.6 mM)
Ethanol:<1 mg/mL
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 5.2097 mL 26.0485 mL 52.0969 mL
5 mM 1.0419 mL 5.2097 mL 10.4194 mL
10 mM 0.5210 mL 2.6048 mL 5.2097 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

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What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

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