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    Droxidopa (L-DOPS; SM5688))
    Droxidopa (L-DOPS; SM5688))

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1138
    CAS #: 23651-95-8 Purity ≥98%

    Description: Droxidopa (also known as L-DOPS; LDOPS; SM 5688; SM-5688; Northera; L-threodihydroxyphenylserine) is a potent psychoactive drug that acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). As a prodrug, Droxidopa is structurally similar to noradrenaline, but with a carboxyl group. Droxidopa can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline. Droxidopa is well tolerated.

    References: Clin Auton Res. 2008 Mar;18 Suppl 1:25-9; Clin Auton Res. 2001 Aug;11(4):235-42.

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    Molecular Weight (MW)213.19 
    FormulaC9H11NO5 
    CAS No.23651-95-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: (2R,3S)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid

    InChi Key: QXWYKJLNLSIPIN-SFYZADRCSA-N

    InChi Code: InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m1/s1

    SMILES Code: O=C(O)[[email protected]](N)[[email protected]](C1=CC=C(O)C(O)=C1)O

    SynonymsL-DOPS; SM5688; Droxidopa; trade name: Northera; LDOPS; SM 5688; SM-5688; L-threodihydroxyphenylserine


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    In Vitro

    In vitro activity: Droxidopa is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. Droxidopa can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline. Droxidopa is well tolerated. Droxidopa could exert its pressor effect in three different ways: a) as a central stimulator of sympathetic activity; b) as a peripheral sympathetic neurotransmitter; c) as a circulating hormone. Droxidopa taken alone increases standing blood pressure. Droxidopa can also cross the blood–brain barrier (BBB) where it is converted to norepinephrine and epinephrine from within the brain.

    In VivoThe acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow. Droxidopa(L-DOPS) is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. It has no pressor effects in this form. It can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline
    Animal modelRats
    Formulation & DosageN/A
    References

    Clin Auton Res. 2008 Mar;18 Suppl 1:25-9; Clin Auton Res. 2001 Aug;11(4):235-42. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Droxidopa

    Plasma levels of droxidopa and norepinephrine after droxidopa administration in 8 subjects with autonomic failure. Expert Rev Cardiovasc Ther. 2015 Aug; 13(8): 875–891.
     

    Droxidopa

    Effects of droxidopa and placebo on mean blood pressure standing. Expert Rev Cardiovasc Ther. 2015 Aug; 13(8): 875–891.


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