| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
D-Erythrose is an anti-cancer agent. In vitro, approximately 4 mM erythrose effectively kills cancer cells for tested cell lines, such as lung, brain, breast, and colorectal cancers. It inhibits tumor growth in mice in vivo. D-Erythrose reduces D-erythrose to erythritol, which inhibits polymerase chain reactions by blocking transcription and replication of DNA.
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|---|---|
| ln Vitro |
In vitro, D-erythrose effectively kills cancer cells for tested cell lines, such as lung, brain, breast, and colorectal cancers. It is used to study the mechanisms of organic microspherule formation and Maillard (glycation) reactions.
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| ln Vivo |
In vivo, D-erythrose significantly inhibited tumor growth in an abdominal metastatic model of colon carcinoma. It inhibits tumor growth in mice.
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| Enzyme Assay |
Dedicated receptor binding assays for D-erythrose are not standard. Its anti-cancer activity is typically assessed using cell viability assays. Its effects on metabolic pathways can be studied using metabolomics approaches.
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| Cell Assay |
Cell-based assays for D-erythrose involve treating cancer cell lines with the compound and measuring cell viability, proliferation, and apoptosis. The compound's ability to kill cancer cells is assessed using standard assays such as the MTT assay.
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| Animal Protocol |
D-erythrose has been studied in animal models of cancer, including an abdominal metastatic model of colon carcinoma. The compound is administered, and its effects on tumor growth and survival are assessed.
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| ADME/Pharmacokinetics |
D-Erythrose has a molecular weight of 120.10 and a molecular formula of C4H8O4. It is typically supplied as a syrup, ca 70% w/v. It is soluble in water. For storage, it should be kept at -20°C.
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| Toxicity/Toxicokinetics |
The toxicological profile of D-erythrose has not been extensively characterized. As a natural sugar, it is generally considered to have low toxicity. However, as with any research compound, appropriate safety precautions should be taken when handling it.
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| Additional Infomation |
D-erythrose is the D-enantiomer of erythrose, a plant metabolite, and also the enantiomer of L-erythrose. Erythrose is found in or produced by Escherichia coli (strains K12 and MG1655). D-erythrose has been reported in brown algae (Roccella fuciformis), Arabidopsis thaliana, and other organisms with relevant data.
D-Erythrose (D-(-)-Erythrose) is a four-carbon aldose sugar that is an important intermediate in various metabolic pathways. It has anti-cancer activity and inhibits tumor growth in vitro and in vivo. It is a valuable research tool for studying cancer, metabolism, and glycation reactions. |
| Molecular Formula |
C4H8O4
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|---|---|
| Molecular Weight |
120.1039
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| Exact Mass |
120.042
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| CAS # |
583-50-6
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| Related CAS # |
L-Erythrose;533-49-3;D-Erythrose-1-13C;70849-19-3;D-Erythrose-2-13C;83434-88-2;D-Erythrose-3-13C;D-Erythrose-4-13C;90913-08-9
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| PubChem CID |
94176
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| Appearance |
Colorless to light yellow liquid（Density：1.05 g/cm3）
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| Density |
1.698 g/cm3
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| Boiling Point |
290.6ºC at 760 mmHg
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| Melting Point |
<25℃
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| Flash Point |
129.5ºC
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| Index of Refraction |
1.498
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| LogP |
-2.2
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
8
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| Complexity |
72.4
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| Defined Atom Stereocenter Count |
2
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| SMILES |
O([H])[C@]([H])(C([H])([H])O[H])[C@]([H])(C([H])=O)O[H]
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| InChi Key |
YTBSYETUWUMLBZ-IUYQGCFVSA-N
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| InChi Code |
InChI=1S/C4H8O4/c5-1-3(7)4(8)2-6/h1,3-4,6-8H,2H2/t3-,4+/m0/s1
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| Chemical Name |
(2R,3R)-2,3,4-trihydroxybutanal
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~250 mg/mL (~2081.60 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.3264 mL | 41.6320 mL | 83.2639 mL | |
| 5 mM | 1.6653 mL | 8.3264 mL | 16.6528 mL | |
| 10 mM | 0.8326 mL | 4.1632 mL | 8.3264 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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