| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 25mg |
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| 50mg | |||
| 100mg | |||
| Other Sizes |
Purity: ≥98%
| Targets |
Cyclosporin C targets cyclophilin, a protein involved in protein folding. By binding to cyclophilin, it inhibits calcineurin, leading to immunosuppression. It also has antifungal activity against filamentous phytopathogenic fungi.
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|---|---|
| ln Vitro |
Cyclosporin C is a broad-spectrum antifungal agent against filamentous phytopathogenic fungi but has no activity against bacteria or yeasts. It also has immunosuppressive properties.
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| ln Vivo |
Cyclosporin C has antifungal and immunosuppressive properties. It is a natural product produced by the fungus Tolypocladium inflatum. It is used in research to study cyclosporin biology.
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| Enzyme Assay |
Cyclosporin C is evaluated in cell-free assays for its ability to inhibit calcineurin. The compound is incubated with calcineurin and a substrate, and the inhibition of enzyme activity is measured.
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| Cell Assay |
Cyclosporin C is assessed in cell-based antifungal assays using fungal cultures. The compound is tested against filamentous phytopathogenic fungi, and growth inhibition is measured. Its immunosuppressive effects are studied in immune cells.
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| Animal Protocol |
Cyclosporin C is administered in animal models to evaluate its antifungal and immunosuppressive effects. However, specific animal study protocols are not extensively documented.
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| ADME/Pharmacokinetics |
Cyclosporin C has a molecular weight of 1218.61 and a molecular formula of C62H111N11O13. It has a CAS number of 59787-61-0. The compound is a cyclic polypeptide. It should be stored under recommended conditions.
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| Toxicity/Toxicokinetics |
No detailed toxicity data is available for Cyclosporin C. The compound is for research use only and is not intended for human therapeutic use.
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| References |
Xu L, Li Y, Biggins JB, Bowman BR, Verdine GL, Gloer JB, Alspaugh JA, Bills GF. Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay. Appl Microbiol Biotechnol. 2018 Mar;102(5):2337-2350.
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| Additional Infomation |
Cyclosporin C is a homocyclic peptide. It has been reported to be found in Fusarium neocosmosporiellum, Gliomastix luzulae, and Trichoderma polysporum, and relevant data are available for reference.
Cyclosporin C is a minor analogue of the cyclosporin complex. It has a CAS number of 59787-61-0. It is a broad-spectrum antifungal agent. It is not approved for clinical use. |
| Molecular Formula |
C62H111N11O13
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|---|---|
| Molecular Weight |
1218.63
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| Exact Mass |
1217.836
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| Elemental Analysis |
C, 61.11; H, 9.18; N, 12.64; O, 17.07
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| CAS # |
59787-61-0
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| Related CAS # |
59787-61-0
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| PubChem CID |
5287817
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| Appearance |
Solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
1316.0±65.0 °C at 760 mmHg
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| Melting Point |
152-155ºC
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| Flash Point |
749.7±34.3 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.472
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| LogP |
2.11
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| Hydrogen Bond Donor Count |
6
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| Hydrogen Bond Acceptor Count |
13
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
86
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| Complexity |
2360
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| Defined Atom Stereocenter Count |
13
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| SMILES |
O([H])C([H])(C([H])(C([H])([H])[H])C([H])([H])/C(/[H])=C(\[H])/C([H])([H])[H])C1([H])C(N([H])C([H])(C(N(C([H])([H])[H])C([H])([H])C(N(C([H])([H])[H])C([H])(C(N([H])C([H])(C(N(C([H])([H])[H])C([H])(C(N([H])C([H])(C([H])([H])[H])C(N([H])C([H])(C([H])([H])[H])C(N(C([H])([H])[H])C([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(N(C([H])([H])[H])C([H])(C(N(C([H])([H])[H])C([H])(C(N1C([H])([H])[H])=O)C([H])(C([H])([H])[H])C([H])([H])[H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=O)=O)=O)=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=O)C([H])(C([H])([H])[H])C([H])([H])[H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=O)=O)C([H])(C([H])([H])[H])O[H])=O
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| InChi Key |
JTOKYIBTLUQVQV-QRVTZXGZSA-N
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| InChi Code |
InChI=1S/C62H111N11O13/c1-25-26-27-39(14)52(76)51-56(80)66-49(42(17)74)60(84)67(18)32-47(75)68(19)43(28-33(2)3)55(79)65-48(37(10)11)61(85)69(20)44(29-34(4)5)54(78)63-40(15)53(77)64-41(16)57(81)70(21)45(30-35(6)7)58(82)71(22)46(31-36(8)9)59(83)72(23)50(38(12)13)62(86)73(51)24/h25-26,33-46,48-52,74,76H,27-32H2,1-24H3,(H,63,78)(H,64,77)(H,65,79)(H,66,80)/b26-25+/t39-,40+,41-,42-,43+,44+,45+,46+,48+,49+,50+,51+,52-/m1/s1
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| Chemical Name |
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(1R)-1-Hydroxyethyl]-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotri-triacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
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| Synonyms |
Cyclosporin C; Cyclosporin-C; CsC; Cs-C;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.8206 mL | 4.1030 mL | 8.2059 mL | |
| 5 mM | 0.1641 mL | 0.8206 mL | 1.6412 mL | |
| 10 mM | 0.0821 mL | 0.4103 mL | 0.8206 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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