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    Ciprofloxacin (Bay-09867)
    Ciprofloxacin (Bay-09867)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1402
    CAS #: 85721-33-1 Purity ≥98%

    Description: Ciprofloxacin (also known as Bay-09867) is a broad-spectrum, fluoroquinolone antibiotic/antimicrobial  which shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target.

    References: Antimicrob Agents Chemother. 1983 Apr;23(4):559-64; Antimicrob Agents Chemother. 1996 Oct;40(10):2321-6.

    Related CAS#: 86393-32-0 (Ciprofloxacin Hydrochloride monohydydrate); 93107-08-5 (Ciprofloxacin Hydrochloride); 85721-33-1  (free base)

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    Molecular Weight (MW)331.34 
    FormulaC17H18FN3O3 
    CAS No.85721-33-1 (free base); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other InfoElemental Analysis: C, 61.62; H, 5.48; F, 5.73; N, 12.68; O, 14.49
    Synonym: Ciprofloxacin; Baflox; Cetraxal; Ciprolin; Fimoflox; Proflaxin; Spitacin;
    IUPAC/Chemical Name: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
    InChi Key: MYSWGUAQZAJSOK-UHFFFAOYSA-N
    InChi Code: InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
    SMILES Code: OC(C1=CN(c2c(C1=O)cc(F)c(N3CCNCC3)c2)C4CC4)=O 
    SynonymsBay-09867; Bay09867; Bay 09867; Baflox; Cetraxal; Ciprolin; Fimoflox; Proflaxin; Spitacin


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    In Vitro

    In vitro activity: Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml.


    Kinase Assay: Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL.


    Cell Assay: Bacterial inocula are prepared by suspending colonies into Mueller-Hinton broth (CAMHB) (containing Ciprofloxacin) from 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) on sheep blood agar (SBA) plates that are incubated at 35°C. Suspended cultures are diluted with CAMHB to a bacterial cell density of 105 CFU/mL adjusted based on the optical density at 600 nm. To each well of the 96-well plate, 50 μL of dilutions is added for a final inoculum of ~5×104 CFU/well. Plates are incubated at 35°C. MICs are determined visually at 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) and also by absorbance at 600 nm

    In VivoCiprofloxacin (Bay-09867) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (Bay-09867) (≥10 μg/L) and enrofloxacin are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin (Bay-09867) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin (Bay-09867). Intraperitoneal Ciprofloxacin (Bay-09867) reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.
    Animal modelFemale BALB/cAnNCrl (BALB/c) mice, 8 to 10 weeks old and 20 g (±4 g) are used in this assay. A single dose of Ciprofloxacin (Bay-09867) (30 mg/kg) is administered to mice (n=30) via the intraperitoneal (i.p.) route. The mice (n=3/time point/group) are culled at 1, 10, 20, or 30 min and 1, 1.5, 2, 4, 8, 12 h following Ciprofloxacin administration and 1, 15, or 30 min and 1, 2, 4, 6, 10, 18, or 24 h following DRCFI or CFI administration. Blood sampling points are chosen based upon the short half-life of Ciprofloxacin and longer half-life of CFI. Blood and lungs (whole organ) are collected post mortem for analysis. The lung doses following CFI or DRCFI administration are calculated using the concentration of Ciprofloxacin in the lung samples at 1 min post-administration
    Formulation & Dosage30 mg/kg; i.p.
    ReferencesAntimicrob Agents Chemother. 1983 Apr;23(4):559-64; Antimicrob Agents Chemother. 1996 Oct;40(10):2321-6. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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