| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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Purity: ≥98%
CAY10505, the dehydroxylated form of AS-252424, is a novel, potent and selective inhibitor of PI3Kγ (phosphoinositide 3-kinase) with a potential to improve hypertension-associated vascular endothelial dysfunction.
| Targets |
PI3Kγ ( IC50 = 30 nM, Neurons)
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| ln Vitro |
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| ln Vivo |
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| Cell Assay |
In neurons treated with 3.5 μM BA, 200 nM CAY10505 partially reduced the baicalein-induced Akt phosphorylation.
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| Animal Protocol |
Wistar albino rats (180-240 g) of either sex are employed in the present study. The number of rats used (n) for each group is 6. Rats are kept in Group I (normal control) on a diet of standard chow and water. Rats in Group II (hypertensive control) are unilaterally nephrectomized (uninephrectomized), given subcutaneous injections of DOCA (40 mg/kg) twice a week for six weeks, and then the untreated drinking water is changed to a 1% NaCl solution. After receiving treatment with DOCA for five weeks, rats in Group III (hypertensive rats) were given CAY10505 (0.6 mg/kg, per os (p.o)) for one week. Rats in Group IV (hypertensive rats) receive treatment with Losartan (25 mg/kg, p.o.) for one week following five weeks of DOCA treatment. Rats in Group V (hypertensive rats) receive Atorvastatin (30 mg/kg, p.o.) for 1 week after receiving DOCA for 5 weeks.
Wistar albino rats
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| References |
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| Molecular Formula |
C14H8FNO3S
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|---|---|
| Molecular Weight |
289.28162
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| Exact Mass |
289.02
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| Elemental Analysis |
C, 58.13; H, 2.79; F, 6.57; N, 4.84; O, 16.59; S, 11.08
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| CAS # |
1218777-13-9
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| Related CAS # |
1218777-13-9
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| Appearance |
Solid powder
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| SMILES |
O=C(NC/1=O)SC1=C\C2=CC=C(C3=CC=C(F)C=C3)O2
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| InChi Key |
UFBTYTGRUBUUIL-KPKJPENVSA-N
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| InChi Code |
InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+
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| Chemical Name |
(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
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| Synonyms |
CAY 10505; CAY10505; CAY-10505
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~58 mg/mL (200.5 mM)
Water: <1 mg/mL Ethanol: <1 mg/mL |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4569 mL | 17.2843 mL | 34.5686 mL | |
| 5 mM | 0.6914 mL | 3.4569 mL | 6.9137 mL | |
| 10 mM | 0.3457 mL | 1.7284 mL | 3.4569 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Effects of PI3K inhibitors on the baicalein–activated HIF1α and Epo/VEGF gene transcription in neurons. Neurons were treated with 3.5 μM BA with or without 1 h pretreatment with the pan PI3K inhibitor LY294002 (LY, 10 μM), PI3Kα/β inhibitor (PI3K α inhibitor-2, 50 nM), or PI3Kγ inhibitor (CAY10505, 200 nM). PLoS One, 2013, 8(7):e69019. |
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