Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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Other Sizes |
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Purity: ≥98%
CaMKII-IN-1, a 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine analog, is a novel, potent and highly selective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) inhibitor with IC50 of 63 nM. In particular, the inhibitory activity of CaMKII-IN-1 was 25-fold higher than that of KN-93, a known CaMKII inhibitor. Michaelis-Menten analysis of a representative compound suggested that the synthesized pyrimidines are calmodulin non-competitive inhibitors. Finally, CaMKII-IN-1 exhibited more than 100-fold higher selectivity for CaMKII over five types of off-target kinases.
References |
Bioorg Med Chem Lett.2010 Nov 15;20(22):6696-8.
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Molecular Formula |
C29H30CLN5O2S
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Molecular Weight |
548.0988
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CAS # |
1208123-85-6
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SMILES |
ClC1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])S(N([H])C1C2=C(C([H])([H])C([H])([H])N(C([H])([H])C3C([H])=C([H])C([H])=C([H])C=3[H])C2([H])[H])N=C(N([H])C([H])([H])C([H])([H])C2C([H])=C([H])C([H])=C([H])C=2[H])N=1)(=O)=O
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ≥ 54 mg/mL (~98.52 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.8245 mL | 9.1224 mL | 18.2448 mL | |
5 mM | 0.3649 mL | 1.8245 mL | 3.6490 mL | |
10 mM | 0.1824 mL | 0.9122 mL | 1.8245 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.