| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
As an industrial chemical and excipient, calcium stearate does not have a specific pharmacological target. It is used as a lubricant, stabilizer, and release agent in various industries, including pharmaceuticals, cosmetics, and food processing. The compound is a salt of stearic acid and is used as an excipient in drug formulations.
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| ln Vitro |
Calcium stearate itself is not known to possess direct therapeutic activity. Its significance is as an excipient and processing aid in pharmaceuticals, cosmetics, and food products. The compound is used as a lubricant, stabilizer, release agent, anticaking agent, and emulsion stabilizing agent. In drug formulations, it is used to improve stability and dissolution rate.
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| ln Vivo |
There is no reported in vivo therapeutic activity for calcium stearate. The compound is primarily used as an excipient and processing aid in pharmaceutical, cosmetic, and food formulations. It is used as a lubricant and release agent in tablet manufacturing.
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| Enzyme Assay |
As an excipient and processing aid, there are no standardized in vitro enzyme/receptor binding assays for calcium stearate. The compound's utility is in improving the physical properties of formulations. Researchers may study the compound's effects on tablet hardness, dissolution, or stability.
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| Cell Assay |
There are no reported in vitro cellular assays for calcium stearate as a therapeutic agent. The compound is used as an excipient in pharmaceutical and cosmetic formulations. Cellular studies may be conducted to assess the compound's biocompatibility or effects on cell viability, but these are not therapeutic assays.
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| Animal Protocol |
There are no reported in vivo animal studies for calcium stearate as a therapeutic agent. The compound is primarily used as an excipient and processing aid. Animal studies may be conducted to assess the compound's safety as a food additive or pharmaceutical excipient.
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| ADME/Pharmacokinetics |
Calcium stearate is a white, fine, bulky powder that is insoluble in water and slightly soluble in hot alcohol and hot vegetable and mineral oils. It has a melting point of 147-149°C and a density of 1.08 g/cm³. The compound is soluble in hot pyridine and slightly soluble in oil, but insoluble in alcohol and ether.
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| Toxicity/Toxicokinetics |
Calcium stearate is considered safe for its intended uses as a food additive and pharmaceutical excipient. It is used as an anticaking agent, cosmetic colorant, emulsion stabilizing agent, and viscosity controlling agent. The compound is generally recognized as safe (GRAS) for use in food and pharmaceutical applications.
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| References | |
| Additional Infomation |
Calcium stearate is the organic calcium salt of stearic acid. It is a component of certain lubricants and surfactants. It contains octadecanoate.
See also: fatty acids, tallow, hydrogenation, calcium salts (notes moved to). Calcium stearate is the calcium salt of stearic acid, a white, odorless, and tasteless powder used as a lubricant, stabilizer, and release agent in various industries. It has a molecular formula of C36H70CaO4 and a molecular weight of 607.02. The compound is used as an anticaking agent, cosmetic colorant, emulsion stabilizing agent, and viscosity controlling agent. In pharmaceuticals, it is used as a lubricant and excipient to improve stability and dissolution rate. |
| Molecular Formula |
C36H70CAO4
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|---|---|
| Molecular Weight |
606.03
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| Exact Mass |
606.489
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| CAS # |
1592-23-0
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| Related CAS # |
Stearic acid;57-11-4;Stearic acid-d2;19905-58-9
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| PubChem CID |
15324
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| Appearance |
White to off-white solid powder
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| Density |
1.08g/cm3
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| Boiling Point |
359.4ºC at 760 mmHg
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| Melting Point |
147-149°C
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| Flash Point |
162.4ºC
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| LogP |
12.51
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
30
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| Heavy Atom Count |
41
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| Complexity |
196
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| Defined Atom Stereocenter Count |
0
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| Synonyms |
AI3 01335; AI3-01335; Calcium stearate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6501 mL | 8.2504 mL | 16.5008 mL | |
| 5 mM | 0.3300 mL | 1.6501 mL | 3.3002 mL | |
| 10 mM | 0.1650 mL | 0.8250 mL | 1.6501 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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