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    Aprotinin
    Aprotinin

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0710
    CAS #: 9087-70-1Purity ≥98%

    Description: Aprotinin is a novel and potent small protein serine protease / bovine pancreatic trypsin inhibitor (BPTI) with antifibrinolytic activity. It inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively. Aprotinin is used to reduce perioperative blood loss and transfusion. The use of aprotinin did not significantly increase the risk of renal failure or the need for postoperative renal replacement despite an increase in the proportion of patients who had a doubling of serum creatinine levels. The adjudication of death did not identify renal failure as contributing to or causing death associated with aprotinin use. A Meta analysis by Brown and colleagues showed a nonsignificant relative risk of renal failure with high-dose aprotinin.

    References: J Mol Recognit. 1997 Jan-Feb;10(1):26-35; J Thromb Haemost. 2007 Oct;5(10):2113-8.

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    Molecular Weight (MW)6511.51
    FormulaC284H432N84O79S7
    CAS No.9087-70-1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (15.4 mM)
    Water:<1 mg/mL
    Ethanol:<1 mg/mL
    Other info
    SMILES: OC([[email protected]@H](NC(CNC(CNC([[email protected]@H](N1)CSSC[[email protected]](NC([[email protected]@H](NC([[email protected]@H](NC([[email protected]@H]2CCCN2C([[email protected]](CCCNC(N)=N)N[H])=O)=O)CC(O)=O)=O)CC3=CC=CC=C3)=O)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCC(O)=O)C(N4CCC[[email protected]]4C(N5CCC[[email protected]]5C(N[[email protected]](C(N[[email protected]]([[email protected]@H](C)O)([H])C(NCC(N6CCC[[email protected]]6C(N[C
    InChi Code: InChI=1S/C284H434N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291
    InChi Key: RWLBZZCCAZDWSE-LPYSRVMUSA-N
    SynonymsBPTI; Aprotinin; Bovine Pancreatic Trypsin Inhibitor; 


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    In Vitro

    In vitro activity: Aprotinin is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. In cell biology, aprotinin is used as an enzyme inhibitor to prevent protein degradation during lysis or homogenization of cells and tissues. In the presence of aprotinin, the fibrinolytic activity is inhibited concentration dependently and the coagulation time is prolonged. Aprotinin is an effective inhibitor of the contact (intrinsic) coagulation pathway in vitro.


    Cell Assay: Mouse G8-1 myoblasts are plated DMEM + 20% FBS (maintenance medium), in which they remain undifferentiated. When cells reach approximately 40-50% confluence, different protease inhibitors are added to the culture media and cells are incubated overnight. Cells are then switched to differentiation-promoting media (DMEM + 10% horse serum ± protease inhibitor) and incubated for 7 days.

    In VivoAprotinin inhibits clot lysis in vitro as well as rat-tail bleeding time in vivo and prolongs coagulation time in human plasma. In a rat arteriovenous shunt model, aprotinin reduces thrombus weight . 
    Animal modelMale Wistar rats 
    Formulation & DosageFormulated in saline; 1.5, 3, 6, 10 mg/kg/h; bolus injection followed by a maintenance infusion (i.p.)
    ReferencesJ Mol Recognit. 1997 Jan-Feb;10(1):26-35; J Thromb Haemost. 2007 Oct;5(10):2113-8.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    Aprotinin
     Evaluation of fibrinolysis in human plasma. J Thromb Haemost. 2007 Oct;5(10):2113-8.
     
    Aprotinin
     Effect of aprotinin and tranexamic acid on fibrinolysis in human plasma. J Thromb Haemost. 2007 Oct;5(10):2113-8.
     
    Aprotinin
     Effect of aprotinin and tranexamic acid on the contact (intrinsic) coagulation pathway in human plasma. J Thromb Haemost. 2007 Oct;5(10):2113-8.
     
    Aprotinin
    Effect of aprotinin and tranexamic acid in a rat-tail bleeding model. J Thromb Haemost. 2007 Oct;5(10):2113-8.
     
    Aprotinin
    Effect of aprotinin and tranexamic acid on thrombus formation induced by contact activation in a rat arteriovenous shunt model. J Thromb Haemost. 2007 Oct;5(10):2113-8.
     
    Aprotinin
    Crystal structure. J Mol Recognit. 1997 Jan-Feb;10(1):26-35.


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