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Ammonium Glycyrrhizinate

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InvivoChem Cat #: V0865

CAS #: 1407-03-0Purity ≥98%

Description: Ammonium Glycyrrhizinate (AMGZ, Glycyram; Monoammonium glycyrrhizinate), a triterpenoid saponin analog, is responsible for the sweet-tasting of Glycyrrhiza glabra root. It acts as a direct HMGB1 antagonist and can potently inhibit growth and cytopathology of several unrelated DNA and RNA viruses. It is cytoprotective agent. Ammonium Glycyrrhizinate is able to inhibit the production of ROS. It has antioxidant activity and is effective for the treatment of gastric diseases related to the oxidative stress-induced mucosal damage.

References: Exp Biol Med. 2009;234(3):263-77; Eksp Klin Farmakol. 1997;60(2):65-7; Int J Nanomedicine. 2014;9:635-51.

Related CAS #: 1405-86-3 (Glycyrrhizic acid)

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Molecular Weight (MW)	839.96
Formula	C42H62O16.NH3
CAS No.	1407-03-0
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 168 mg/mL (200.0 mM)
	Water: 5 mg/mL (5.95 mM)
	Ethanol: <1 mg/mL
SMILES	C[[email protected]]12[[email protected]@](C(C=C3[[email protected]]2(CC[[email protected]]4(C)[[email protected]@]3([H])C[[email protected]](C(O)=O)(C)CC4)C)=O)([H])[[email protected]@]5([[email protected]@](C(C)([[email protected]@H](O[[email protected]]6([H])[[email protected]@H]([[email protected]]([[email protected]](O)[[email protected]@H](C(O)=O)O6)O)O[[email protected]]7([H])O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]]7O)C(O)=O)CC5)C)([H])CC1)C.N
Synonyms	AMGZ, Glycyram; Monoammonium glycyrrhizinate

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In Vitro	In vitro activity: Ammonium glycyrrhizinate (AG) prepared from glycyrrhizin dramatically protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also inhibits FeSO(4)-induced reactive oxygen radicals in a dose-dependent manner, suggesting the role for AG as a free radical scavenger.
In Vivo	Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate-loaded nonionic surfactant vesicles (NSVs) decreases edema and nociceptive responses when compared with Ammonium glycyrrhizinate alone and empty NSVs in mice model. Ammonium glycyrrhizinate up-regulates interleukin-10 (IL-10) level and down-regulates the tumor neurosis factor-α (TNF-α) level and inhibits the cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) activity in the lung tissue of mice. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate significantly decreases triglyceride, cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels in rats. Ammonium glycyrrhizinate increases high density lipoprotein (HDL) levels increased in rats.
Animal model	Mice and rats
Formulation & Dosage	28 mg/kg
References	Exp Biol Med (Maywood). 2009 Mar;234(3):263-77; Eksp Klin Farmakol. 1997 Mar-Apr;60(2):65-7; Int J Nanomedicine. 2014 Jan 24;9:635-51.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Purity ≥98%
COA
MSDS

Transmission electron micrographs of nonionic surfactant vesicles after freeze-fracture. F1 (A), F1AG (B), F3 (C), and F3AG (D). Scale bars, 150 nm. Int J Nanomedicine.2014 Jan 24;9:635-51.	Niosomes on Turbiscan Lab® Expert. Int J Nanomedicine. 2014 Jan 24;9:635-51.	In vitro release of AG from nonionic surfactant vesicles. Int J Nanomedicine. 2014 Jan 24;9:635-51.

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