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      Ammonium Glycyrrhizinate
      Ammonium Glycyrrhizinate

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      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V0865
      CAS #: 1407-03-0Purity ≥98%

      Description: Ammonium Glycyrrhizinate (AMGZ, Glycyram; Monoammonium glycyrrhizinate), a triterpenoid saponin analog, is responsible for the sweet-tasting of Glycyrrhiza glabra root. It acts as a direct HMGB1 antagonist and can potently  inhibit growth and cytopathology of several unrelated DNA and RNA viruses. It is cytoprotective agent. Ammonium Glycyrrhizinate is able to inhibit the production of ROS. It has antioxidant activity and is effective for the treatment of gastric diseases related to the oxidative stress-induced mucosal damage.

      References: Exp Biol Med. 2009;234(3):263-77; Eksp Klin Farmakol. 1997;60(2):65-7; Int J Nanomedicine. 2014;9:635-51.

      Related CAS #: 1405-86-3 (Glycyrrhizic acid)

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      Molecular Weight (MW)839.96
      FormulaC42H62O16.NH3
      CAS No.1407-03-0
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 168 mg/mL (200.0 mM)
      Water: 5 mg/mL (5.95 mM)
      Ethanol: <1 mg/mL
      SMILESC[[email protected]]12[[email protected]@](C(C=C3[[email protected]]2(CC[[email protected]]4(C)[[email protected]@]3([H])C[[email protected]](C(O)=O)(C)CC4)C)=O)([H])[[email protected]@]5([[email protected]@](C(C)([[email protected]@H](O[[email protected]]6([H])[[email protected]@H]([[email protected]]([[email protected]](O)[[email protected]@H](C(O)=O)O6)O)O[[email protected]]7([H])O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]]7O)C(O)=O)CC5)C)([H])CC1)C.N
      SynonymsAMGZ, Glycyram; Monoammonium glycyrrhizinate


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      In Vitro

      In vitro activity: Ammonium glycyrrhizinate (AG) prepared from glycyrrhizin dramatically protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also inhibits FeSO(4)-induced reactive oxygen radicals in a dose-dependent manner, suggesting the role for AG as a free radical scavenger.

      In VivoAmmonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate-loaded nonionic surfactant vesicles (NSVs) decreases edema and nociceptive responses when compared with Ammonium glycyrrhizinate alone and empty NSVs in mice model. Ammonium glycyrrhizinate up-regulates interleukin-10 (IL-10) level and down-regulates the tumor neurosis factor-α (TNF-α) level and inhibits the cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) activity in the lung tissue of mice. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate significantly decreases triglyceride, cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels in rats. Ammonium glycyrrhizinate increases high density lipoprotein (HDL) levels increased in rats.
      Animal modelMice and rats
      Formulation & Dosage28 mg/kg
      References

      Exp Biol Med (Maywood). 2009 Mar;234(3):263-77; Eksp Klin Farmakol. 1997 Mar-Apr;60(2):65-7; Int J Nanomedicine. 2014 Jan 24;9:635-51.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

      Transmission electron micrographs of nonionic surfactant vesicles after freeze-fracture. F1 (A), F1AG (B), F3 (C), and F3AG (D). Scale bars, 150 nm. Int J Nanomedicine.2014 Jan 24;9:635-51. 
      		 
      Ammonium Glycyrrhizinate
      Niosomes on Turbiscan Lab® Expert. Int J Nanomedicine. 2014 Jan 24;9:635-51. 
      		 
      Ammonium Glycyrrhizinate
      In vitro release of AG from nonionic surfactant vesicles. Int J Nanomedicine. 2014 Jan 24;9:635-51. 

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