My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Ambroxol HCl (NA-872)
    Ambroxol HCl (NA-872)

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1661
    CAS #: 23828-92-4 Purity ≥98%

    Description: Ambroxol HCl (NA-872), a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus, is a novel and potent inhibitor of the neuronal Na+ channels, which inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Ambroxol inhibits Na+ channels in sensory neurons. The potency for tonic block of TTX-r channels is relatively high. Ambroxol affects the Na+ current kinetics of TTX-r and TTX-s channels differently. 

    References: Mol Pharmacol. 2002 Sep;62(3):433-8; Inflamm Res. 1999 Feb;48(2):86-93.

    Related CAS#: 18683-91-5 (free)

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)414.56 
    FormulaC13H18Br2N2O.HCl 
    CAS No.23828-92-4 (HCl); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 4 mg/mL (9.6 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info
    Chemical Name: 4-((2-amino-3,5-dibromophenyl)(methyl)amino)cyclohexan-1-ol hydrochloride
    InChi Key: BHQINQPCRNWCHB-UHFFFAOYSA-N
    InChi Code: InChI=1S/C13H18Br2N2O.ClH/c1-17(9-2-4-10(18)5-3-9)12-7-8(14)6-11(15)13(12)16;/h6-7,9-10,18H,2-5,16H2,1H3;1H
    SMILES Code: OC1CCC(N(C2=CC(Br)=CC(Br)=C2N)C)CC1.[H]Cl 
    SynonymsNA-872; NA872; NA 872; Abrohexal; Ambril; Ambro-Puren Ambrobeta; Duramucal; Ebromin; Mucosolvan 


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: Ambroxol inhibits Na+ channels in sensory neurons. The potency for tonic block of TTX-r channels is relatively high. Ambroxol affects the Na+ current kinetics of TTX-r and TTX-s channels differently. In CNaIIA cells, the compound behaves like a charged local anesthetic: the block is dependent on stimulus number and increases with higher frequencies in a train of depolarizing stimuli. In CNaIIA cells, ambroxol inhibits inactivated channels 5.5-fold more potently than resting channels. The corresponding factor for TTX-r channels is only 3.3. Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.

    In VivoAmbroxol inhibited histamine release by more than 50% from human adenoidal mast cells (1000 microM ambroxol) and skin mast cells (100 microM ambroxol) stimulated by Con A and compound 48/80, respectively. Ambroxol (100 microM) strikingly inhibited anti-IgE induced release of both histamine, LTC4, IL-4 and IL-13 from basophils and reduced both histamine and LTB4 release induced by C5a or Zymosan in monocytes. The drug also reduced LTB4 and superoxide anion production in granulocytes stimulated by zymosan or fMLP. 
    Animal model
    Formulation & Dosage
    ReferencesMol Pharmacol. 2002 Sep;62(3):433-8; Inflamm Res. 1999 Feb;48(2):86-93. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?