| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| Other Sizes |
| Targets |
Abscisic acid-d6 targets the same receptors as abscisic acid, including PYR/PYL/RCAR (pyrabactin resistance/PYR1-like/regulatory components of ABA receptor) family of proteins, which are soluble receptors that initiate ABA signaling. ABA also targets protein phosphatases PP2C and activates SnRK2 kinases, leading to stress-responsive gene expression. However, as a labeled compound, ABA-d6 is used as an analytical standard rather than for its biological activity.
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|---|---|
| ln Vitro |
Abscisic acid-d6 is not evaluated for in vitro biological activity as a drug; it is a stable isotope-labeled internal standard. The parent compound abscisic acid is a plant hormone that regulates stress responses, seed dormancy, and stomatal closure. However, the labeled version is used for analytical purposes and does not have intrinsic pharmacological activity as a drug.
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| ln Vivo |
Abscisic acid-d6 is not administered as a therapeutic agent and does not have intrinsic in vivo pharmacological activity in animals. It is used as an internal standard for the quantification of abscisic acid in biological samples (plant tissues, plasma, urine) using LC-MS/MS. The labeled compound allows for precise and accurate measurement of endogenous ABA levels.
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| Enzyme Assay |
There are no specific in vitro enzyme or receptor binding assays for Abscisic acid-d6 as a drug target. As an internal standard, it is used in analytical chemistry rather than biological assays. The compound is characterized by its isotopic purity and chemical purity, which are confirmed by NMR and mass spectrometry.
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| Cell Assay |
There are no specific in vitro cellular assays for Abscisic acid-d6 as a pharmacologically active compound. As an internal standard, it is used in sample preparation for LC-MS/MS analysis. The compound is added to biological samples at known concentrations to correct for matrix effects and extraction efficiency.
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| Animal Protocol |
There are no specific in vivo animal studies for Abscisic acid-d6 as a pharmacologically active compound. As an internal standard, it is used in the analysis of biological samples from animal studies. The compound is not administered to animals as a therapeutic agent.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Abscisic acid-d6 are not studied as a drug; it is an analytical internal standard. The labeled compound has similar physicochemical properties to abscisic acid, including moderate lipophilicity and poor oral bioavailability. It is typically used in trace amounts for analytical purposes.
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| Toxicity/Toxicokinetics |
The toxicity profile of Abscisic acid-d6 is not reported, as it is a stable isotope-labeled research compound used in trace amounts. The parent compound abscisic acid is a plant hormone and is generally considered non-toxic to animals at physiological concentrations. The compound is for research use only and not for human therapeutic use.
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| References | |
| Additional Infomation |
Abscisic acid-d6 (CAS 721948-65-8, ABA-d6) is a deuterium-labeled form of abscisic acid used as an internal standard for mass spectrometry-based quantification. Abscisic acid is a plant hormone involved in stress responses, seed dormancy, and stomatal closure. The compound has six deuterium atoms and is available as a research-grade standard. It is not approved for clinical use and is strictly for research purposes only.
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| Molecular Formula |
C15H20O4
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|---|---|
| Molecular Weight |
270.353875160217
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| Exact Mass |
270.173
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| CAS # |
721948-65-8
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| Related CAS # |
Abscisic acid;21293-29-8;(±)-trans-Abscisic acid;2228-72-0
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| PubChem CID |
46779839
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
458.7±45.0 °C at 760 mmHg
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| Flash Point |
245.4±25.2 °C
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| Vapour Pressure |
0.0±2.5 mmHg at 25°C
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| Index of Refraction |
1.583
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| LogP |
1.7
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
19
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| Complexity |
494
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| Defined Atom Stereocenter Count |
1
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| SMILES |
[2H]C1=C([C@@](C(C(C1=O)([2H])[2H])(C)C)(/C=C/C(=C\C(=O)O)/C)O)C([2H])([2H])[2H]
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| InChi Key |
JLIDBLDQVAYHNE-CKOUZVSSSA-N
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| InChi Code |
InChI=1S/C15H20O4/c1-10(7-13(17)18)5-6-15(19)11(2)8-12(16)9-14(15,3)4/h5-8,19H,9H2,1-4H3,(H,17,18)/b6-5+,10-7-/t15-/m1/s1/i2D3,8D,9D2
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| Chemical Name |
(2Z,4E)-3-methyl-5-[(1S)-3,5,5-trideuterio-1-hydroxy-6,6-dimethyl-4-oxo-2-(trideuteriomethyl)cyclohex-2-en-1-yl]penta-2,4-dienoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6989 mL | 18.4945 mL | 36.9891 mL | |
| 5 mM | 0.7398 mL | 3.6989 mL | 7.3978 mL | |
| 10 mM | 0.3699 mL | 1.8495 mL | 3.6989 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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