| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 50mg |
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| Other Sizes |
| Targets |
The primary target of Tetracosane-d50 is not a biological target but rather its use as an analytical internal standard. It is used in GC-MS and NMR spectroscopy as a reference standard for the quantification of hydrocarbons and other analytes. Its high deuterium content makes it an ideal standard for mass spectrometry and NMR spectroscopy.
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| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
Tetracosane-d50 does not exhibit any in vitro biological activity as it is an inert alkane used as an analytical standard. It is not a bioactive compound and is not tested in biological assays. Its utility is in analytical chemistry rather than biological research. |
| ln Vivo |
Tetracosane-d50 is not intended for in vivo administration as a therapeutic agent; it is used as an analytical standard. It has no in vivo biological activity and is not used in animal studies for therapeutic efficacy.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for Tetracosane-d50 are not applicable, as it is an analytical standard. Quality control assays involve GC-MS or NMR spectroscopy to verify isotopic purity (≥98 atom % D) and chemical purity (≥95%). The compound is tested for stability under various storage conditions. It appears as a solid with a melting point of 49-52°C and a boiling point of 391°C.
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| Cell Assay |
Tetracosane-d50 is not tested in in vitro cellular assays for biological activity, as it is an analytical standard. Its utility is assessed by its performance as an internal standard in analytical workflows, including its ability to provide accurate quantification in GC-MS and NMR analyses. The compound is used in quality control applications for hydrocarbon analysis.
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| Animal Protocol |
In vivo animal studies for Tetracosane-d50 are not conducted as therapeutic efficacy studies. It is used in environmental studies, such as simulating weathering experiments on mixed oils. The compound is not administered to animals for pharmacokinetic studies.
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| ADME/Pharmacokinetics |
Tetracosane-d50 has a molecular formula of C24D50 and a molecular weight of 388.96. It has a purity of ≥95% and an isotopic enrichment of ≥98 atom % D. It appears as a solid with a melting point of 49-52°C and a boiling point of 391°C. It is soluble in organic solvents. It is intended for research use only and is not for human consumption.
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| Toxicity/Toxicokinetics |
The toxicity profile of Tetracosane-d50 is not extensively characterized, as it is an analytical standard rather than a therapeutic agent. The parent compound Tetracosane is a straight-chain alkane that is generally considered to have low toxicity. Tetracosane-d50 is intended for research use only and is not approved for clinical use. Standard laboratory safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
Tetracosane-d50 (CAS 16416-32-3) is a perdeuterated straight-chain alkane (C24D50) used exclusively as an isotopically labeled internal standard in GC-MS and NMR spectroscopy. It is a highly deuterated form of Tetracosane, where fifty hydrogen atoms are replaced with deuterium. It is used in simulated weathering experiments on mixed oils. It is intended for research use only and is not approved for clinical use.
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| Molecular Formula |
C24D50
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|---|---|
| Molecular Weight |
388.96
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| Exact Mass |
388.705
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| CAS # |
16416-32-3
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| Related CAS # |
Tetracosane;646-31-1
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| PubChem CID |
27870
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| Appearance |
White to off-white solid powder
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| Density |
0.8±0.1 g/cm3
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| Boiling Point |
391.1±5.0 °C at 760 mmHg
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| Melting Point |
49-52ºC(lit.)
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| Flash Point |
234.5±7.2 °C
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| Vapour Pressure |
0.0±0.4 mmHg at 25°C
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| Index of Refraction |
1.446
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| LogP |
13.51
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
0
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| Rotatable Bond Count |
21
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| Heavy Atom Count |
24
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| Complexity |
174
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
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| InChi Key |
POOSGDOYLQNASK-KNUOVWDMSA-N
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| InChi Code |
InChI=1S/C24H50/c1-3-5-7-9-11-13-15-17-19-21-23-24-22-20-18-16-14-12-10-8-6-4-2/h3-24H2,1-2H3/i1D3,2D3,3D2,4D2,5D2,6D2,7D2,8D2,9D2,10D2,11D2,12D2,13D2,14D2,15D2,16D2,17D2,18D2,19D2,20D2,21D2,22D2,23D2,24D2
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| Chemical Name |
1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,24-pentacontadeuteriotetracosane
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5710 mL | 12.8548 mL | 25.7096 mL | |
| 5 mM | 0.5142 mL | 2.5710 mL | 5.1419 mL | |
| 10 mM | 0.2571 mL | 1.2855 mL | 2.5710 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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