| Size | Price | Stock | Qty |
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| 5mg |
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| Other Sizes |
| Targets |
DL-Syringaresinol targets multiple cellular pathways. As a lignan, it is known to have antioxidant properties, scavenging free radicals and reducing oxidative stress. It also exhibits anti-inflammatory effects by modulating the production of inflammatory mediators. Additionally, it has been shown to have anticancer activity by inhibiting cell proliferation and inducing apoptosis.
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| ln Vitro |
In vitro, DL-Syringaresinol demonstrates antioxidant, anti-inflammatory, and anticancer activities. It scavenges free radicals, reducing oxidative stress. It inhibits the production of pro-inflammatory cytokines and mediators. In cancer cell lines, it inhibits cell proliferation and induces apoptosis. These activities make it a compound of interest for studying the health benefits of lignans.
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| ln Vivo |
In vivo, DL-Syringaresinol has demonstrated various pharmacological effects in animal models. Its antioxidant and anti-inflammatory activities have been observed in models of oxidative stress and inflammation. Its anticancer activity has been demonstrated in xenograft models.
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| Enzyme Assay |
The biological activities of DL-Syringaresinol are assessed using various in vitro assays. Its antioxidant activity is measured using DPPH or ABTS radical scavenging assays. Its anti-inflammatory activity is evaluated by measuring its effect on the production of inflammatory mediators in stimulated immune cells. Its anticancer activity is assessed in cell viability and apoptosis assays.
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| Cell Assay |
The cellular activity of DL-Syringaresinol is evaluated in various cell lines, including cancer cells and immune cells. Cells are treated with the compound, and its effects on cell viability, apoptosis, inflammatory markers, and oxidative stress are measured.
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| Animal Protocol |
In animal studies, DL-Syringaresinol is typically administered to rodents via oral or intraperitoneal injection. Its effects on inflammation, tumor growth, or oxidative stress are assessed.
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| ADME/Pharmacokinetics |
DL-Syringaresinol is a lignan with a molecular weight of approximately 400 g/mol. It is soluble in organic solvents such as DMSO and ethanol. Its pharmacokinetic properties are characteristic of polyphenolic compounds.
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| Toxicity/Toxicokinetics |
Toxicology data for DL-Syringaresinol is limited. As a naturally occurring compound, it is generally considered to have a low toxicity profile.
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| References | |
| Additional Infomation |
Syringaresinol is a lignan with the structure 7,9':7',9-diepoxylignanane, where hydroxyl groups are substituted at positions 4 and 4', and methoxy groups are substituted at positions 3, 3', 5, and 5'. It is a plant metabolite. Syringaresinol is a lignan, polyphenol, aromatic ether, furan, and polyether. It has been reported to be found in Sarcopyramis nepalensis, Raphanus sativus var. sativus, and other organisms with relevant data.
DL-Syringaresinol (CAS: 1177-14-6) is a naturally occurring lignan with a range of biological activities. It is a valuable research tool for studying the biological activities of lignans and for exploring their potential therapeutic applications in oxidative stress, inflammation, and cancer. |
| Molecular Formula |
C22H26O8
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|---|---|
| Molecular Weight |
418.43704
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| Exact Mass |
418.162
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| CAS # |
1177-14-6
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| Related CAS # |
1177-14-6
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| PubChem CID |
100067
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
594.7±50.0 °C at 760 mmHg
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| Melting Point |
210 - 211 °C
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| Flash Point |
313.5±30.1 °C
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| Vapour Pressure |
0.0±1.7 mmHg at 25°C
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| Index of Refraction |
1.578
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| LogP |
0.71
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
30
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| Complexity |
485
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=CC(C2OCC3C(C4C=C(OC)C(O)=C(OC)C=4)OCC23)=CC(OC)=C1O
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| InChi Key |
KOWMJRJXZMEZLD-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C22H26O8/c1-25-15-5-11(6-16(26-2)19(15)23)21-13-9-30-22(14(13)10-29-21)12-7-17(27-3)20(24)18(8-12)28-4/h5-8,13-14,21-24H,9-10H2,1-4H3
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| Chemical Name |
4-[6-(4-hydroxy-3,5-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2,6-dimethoxyphenol
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| Synonyms |
DL-Syringaresinol; (±)-Syringaresinol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3898 mL | 11.9491 mL | 23.8983 mL | |
| 5 mM | 0.4780 mL | 2.3898 mL | 4.7797 mL | |
| 10 mM | 0.2390 mL | 1.1949 mL | 2.3898 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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