| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| Other Sizes |
| Targets |
Apigenin 7-O-malonylglucoside targets multiple cellular pathways involved in oxidative stress, inflammation, and cancer cell proliferation. As a flavonoid, it can modulate various signaling pathways, including those involved in apoptosis and cell cycle regulation. Its antioxidant activity allows it to scavenge free radicals. Its anti-inflammatory effects are mediated through the modulation of inflammatory mediators.
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|---|---|
| ln Vitro |
In vitro, apigenin 7-O-malonylglucoside demonstrates antioxidant, anti-inflammatory, and anticancer activities. It scavenges free radicals, reducing oxidative stress. It modulates inflammatory mediators and may inhibit cancer cell growth through apoptosis and cell cycle arrest. These activities make it a compound of interest for studying the health benefits of flavonoids.
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| ln Vivo |
In vivo data for apigenin 7-O-malonylglucoside is limited in publicly available sources. As a natural product, its effects are often studied in the context of dietary intake or as a component of herbal extracts. Its potential benefits are inferred from studies on apigenin and other related flavonoids.
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| Enzyme Assay |
The biological activities of apigenin 7-O-malonylglucoside are assessed using various in vitro assays. Its antioxidant activity is measured using DPPH or ABTS radical scavenging assays. Its anti-inflammatory activity is assessed by measuring its effect on cytokine production in stimulated immune cells. Its anticancer activity is evaluated in cell viability and apoptosis assays using cancer cell lines.
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| Cell Assay |
The cellular activity of apigenin 7-O-malonylglucoside is evaluated in various cell lines, including cancer cells and immune cells. Cells are treated with the compound, and its effect on cell viability, apoptosis, inflammatory markers, and oxidative stress is measured.
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| Animal Protocol |
In vivo studies for apigenin 7-O-malonylglucoside would typically involve administering the compound to animal models of disease. Its effects on inflammation, tumor growth, or oxidative stress would be assessed. However, specific studies are not detailed in the available literature.
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| ADME/Pharmacokinetics |
Apigenin 7-O-malonylglucoside is a flavonoid glycoside with a molecular weight of 518.42. It is soluble in DMSO. Its pharmacokinetic properties, such as absorption and bioavailability, are characteristic of flavonoids and are influenced by its glycoside structure.
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| Toxicity/Toxicokinetics |
Toxicology data for apigenin 7-O-malonylglucoside is limited. As a naturally occurring compound, it is generally considered to have a low toxicity profile. However, formal toxicology studies have not been conducted for this specific compound.
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| References | |
| Additional Infomation |
Apigenin 7-O-(6-malonyl-β-D-glucoside) belongs to the flavonoid family and is a glycoside. It has been reported that apigenin 7-(6''-malonylglucoside) is found in North American peppermint (Monarda punctata) and artichoke (Cynara cardunculus), and relevant data are available.
Apigenin 7-O-malonylglucoside (CAS: 86546-87-4) is a research-grade flavonoid glycoside used to study the biological activities of flavonoids. Its notable antioxidant, anti-inflammatory, and anticancer properties make it a compound of interest for nutraceutical and pharmaceutical research. It serves as a tool for understanding the mechanisms by which dietary flavonoids exert their health benefits. |
| Molecular Formula |
C24H22O13
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|---|---|
| Molecular Weight |
518.42
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| Exact Mass |
535.109
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| CAS # |
86546-87-4
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| PubChem CID |
5281602
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| Appearance |
White to off-white solid powder
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| LogP |
-0.3
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| Hydrogen Bond Donor Count |
6
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| Hydrogen Bond Acceptor Count |
13
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
37
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| Complexity |
882
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| Defined Atom Stereocenter Count |
5
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| SMILES |
C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)COC(=O)CC(=O)O)O)O)O)O)O
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| InChi Key |
JXWAQRJFONLTSI-ASDZUOGYSA-N
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| InChi Code |
InChI=1S/C24H22O13/c25-11-3-1-10(2-4-11)15-7-14(27)20-13(26)5-12(6-16(20)36-15)35-24-23(33)22(32)21(31)17(37-24)9-34-19(30)8-18(28)29/h1-7,17,21-26,31-33H,8-9H2,(H,28,29)/t17-,21-,22+,23-,24-/m1/s1
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| Chemical Name |
3-oxo-3-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxan-2-yl]methoxy]propanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9289 mL | 9.6447 mL | 19.2894 mL | |
| 5 mM | 0.3858 mL | 1.9289 mL | 3.8579 mL | |
| 10 mM | 0.1929 mL | 0.9645 mL | 1.9289 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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