| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
Purity: ≥98%
| References | |
|---|---|
| Additional Infomation |
β-Alanine is a naturally occurring β-amino acid composed of propionic acid molecules with the amino group at the 3-position. It has multiple functions, including as an inhibitor, agonist, human metabolite, basic metabolite, and neurotransmitter. It is the conjugate acid of β-alanine and also the zwitterion tautomer of β-alanine. β-Alanine is an amino acid produced in vivo by the degradation of dihydrouracil and carnosine. Since neurons have been shown to take up β-alanine, and neuronal receptors are sensitive to β-alanine, this compound may be a pseudo-neurotransmitter alternative to γ-aminobutyric acid (GABA). A rare genetic disorder, hyperβ-alanineemia, has been reported. β-Alanine is present in or produced by Escherichia coli (K12 strain, MG1655 strain). It has also been reported in Neurospora alfalfa, potatoes, and other organisms with relevant data. β-Alanine is the only naturally occurring β-amino acid with the amino group at the - position of the carboxyl group. It is formed in vivo by the degradation of dihydrouracil and carnosine. It is a component of the natural peptides carnosine and anserine, and also a component of pantothenic acid (vitamin B5), which itself is a component of coenzyme A. Under normal circumstances, β-alanine is metabolized to acetic acid. Since neurons have been shown to take up β-alanine, and neuronal receptors are sensitive to β-alanine, this compound may be a pseudo-neuronalant that substitutes for γ-aminobutyric acid (GABA). There have been reports on a rare genetic disorder—hyperβ-alanineemia. β-alanine is an amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neurons have been shown to take up β-alanine, and neuronal receptors are sensitive to β-alanine, this compound may be a pseudo-neuronalant that substitutes for GABA. There have been reports on a rare genetic disorder—hyperβ-alanineemia.
|
| Molecular Formula |
C3H7NO2
|
|---|---|
| Molecular Weight |
89.0932
|
| Exact Mass |
89.047
|
| CAS # |
107-95-9
|
| Related CAS # |
25513-34-2;16690-93-0 (mono-hydrochloride salt);36321-40-1 (calcium (2:1) salt);39748-53-3 (mono-potassium salt)
|
| PubChem CID |
239
|
| Appearance |
White to off-white solid powder
|
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
237.1±23.0 °C at 760 mmHg
|
| Melting Point |
202 °C (dec.)(lit.)
|
| Flash Point |
97.2±22.6 °C
|
| Vapour Pressure |
0.0±1.0 mmHg at 25°C
|
| Index of Refraction |
1.463
|
| LogP |
-0.86
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
6
|
| Complexity |
52.8
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
UCMIRNVEIXFBKS-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)
|
| Chemical Name |
3-aminopropanoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 11.2246 mL | 56.1230 mL | 112.2460 mL | |
| 5 mM | 2.2449 mL | 11.2246 mL | 22.4492 mL | |
| 10 mM | 1.1225 mL | 5.6123 mL | 11.2246 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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