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| Other Sizes |
| Targets |
Z-Ser-Ome is classified as a protected amino acid derivative and a serine analogue. It does not have a specific biological receptor target. The Z group and methyl ester provide orthogonal protection for the N- and C-termini, respectively. Its primary application is in peptide synthesis for introducing L-serine residues, which are important for phosphorylation and glycosylation sites in peptides and proteins.
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| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
In vitro activity for Z-Ser-Ome is primarily as a peptide synthesis intermediate. Amino acid derivatives have been studied as ergogenic supplements. Z-Ser-Ome itself is not directly biologically active. Its utility is in preparing serine-containing peptides for subsequent biological evaluation. The side-chain hydroxyl can be used for further chemical modifications. |
| ln Vivo |
In vivo activity data for Z-Ser-Ome as a standalone compound is not applicable. It is a protected amino acid derivative used as a research intermediate. The compound is not intended for direct in vivo administration. Peptides synthesized using this building block may be evaluated in animal models. The protecting groups are typically removed before biological testing.
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| Enzyme Assay |
In vitro protocols for Z-Ser-Ome are primarily synthetic. It is used as an intermediate in peptide synthesis. The methyl ester can be hydrolyzed under basic conditions, and the Z group can be removed by hydrogenolysis. Standard coupling chemistry can be employed. Purity is typically high. Storage is recommended in a cool, dry place.
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| Cell Assay |
Cell-based protocols are not applicable to Z-Ser-Ome as it is a protected amino acid derivative. It is not typically used in cell culture. Biological testing would be performed on the final, deprotected compounds synthesized from this intermediate.
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| Animal Protocol |
Animal studies are not conducted with Z-Ser-Ome directly. The compound may be used as a synthetic intermediate to prepare compounds for pharmaceutical research. The methyl ester and Z protecting groups are typically removed before any biological testing.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Z-Ser-Ome are not applicable as it is a research intermediate. It is a solid at room temperature. Storage is recommended in a cool, dry place. The Z and methyl ester groups are removed during peptide synthesis.
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| Toxicity/Toxicokinetics |
Limited toxicological data is available for Z-Ser-Ome. The compound is for research use only. Standard safety precautions should be observed. No specific toxicity studies have been reported. It is not intended for human therapeutic use.
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| References |
[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
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| Additional Infomation |
Z-Ser-Ome (CAS#: 1676-81-9) is also known as N-Cbz-L-serine methyl ester. Its molecular formula is C12H15NO5. It is a protected serine building block for peptide synthesis. It has no approved therapeutic indications.
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| Molecular Formula |
C12H15NO5
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|---|---|
| Molecular Weight |
253.2512
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| Exact Mass |
253.095
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| CAS # |
1676-81-9
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| PubChem CID |
6999535
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| Appearance |
<41°C powder, >43°C liquid
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
442.6±45.0 °C at 760 mmHg
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| Melting Point |
41-43 °C(lit.)
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| Flash Point |
221.5±28.7 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.536
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| LogP |
1.42
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
18
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| Complexity |
276
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| Defined Atom Stereocenter Count |
1
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| SMILES |
COC([C@@H](NC(OCC1=CC=CC=C1)=O)CO)=O
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| InChi Key |
CINAUOAOVQPWIB-JTQLQIEISA-N
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| InChi Code |
InChI=1S/C12H15NO5/c1-17-11(15)10(7-14)13-12(16)18-8-9-5-3-2-4-6-9/h2-6,10,14H,7-8H2,1H3,(H,13,16)/t10-/m0/s1
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| Chemical Name |
methyl (2S)-3-hydroxy-2-(phenylmethoxycarbonylamino)propanoate
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| Synonyms |
Z-Ser-Ome
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9487 mL | 19.7433 mL | 39.4867 mL | |
| 5 mM | 0.7897 mL | 3.9487 mL | 7.8973 mL | |
| 10 mM | 0.3949 mL | 1.9743 mL | 3.9487 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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