| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg | |||
| Other Sizes |
| Targets |
Yuanhuanin does not have a well-defined specific pharmacological target in the available literature. As a natural flavonoid, it may interact with multiple molecular targets, including enzymes involved in inflammation and oxidative stress. Flavonoids are known to modulate signaling pathways such as NF-κB, MAPK, and PI3K/Akt. They can also act as antioxidants by scavenging free radicals and chelating metal ions. Further research is needed to identify the specific targets of yuanhuanin.
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|---|---|
| ln Vitro |
In vitro, yuanhuanin is expected to exhibit activities typical of flavonoids, such as antioxidant, anti-inflammatory, and potential anticancer effects. However, specific in vitro activity data for yuanhuanin, such as IC50 values against specific targets, are not reported in the available literature. As a natural product, its activity is often studied in the context of its source plant's traditional medicinal uses. It may be used in cell-based assays to assess its effects on cell viability, oxidative stress, or inflammatory markers.
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| ln Vivo |
In vivo, yuanhuanin is used as a research chemical for life sciences research. Its in vivo effects have not been extensively characterized in the available literature. As a flavonoid glycoside, it may have limited oral bioavailability due to its sugar moiety, but it could be hydrolyzed to its aglycone form in the gastrointestinal tract. Further studies are needed to determine its pharmacokinetic and pharmacodynamic properties in animal models.
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| Enzyme Assay |
Non-cellular in vitro assays for yuanhuanin are not well-established in the available literature. As a natural product, its purity and identity can be determined by HPLC and mass spectrometry. Its antioxidant activity can be measured using cell-free assays such as DPPH radical scavenging or ABTS assays. The compound is incubated with the radical solution, and the decrease in absorbance is measured spectrophotometrically. The IC50 for radical scavenging can be calculated.
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| Cell Assay |
Specific cellular assays for yuanhuanin are not reported in the available literature. However, as a flavonoid, it could be tested in various cell lines to assess its biological activities. For example, macrophages or microglia cells could be treated with yuanhuanin and stimulated with LPS to measure the inhibition of inflammatory cytokine production (e.g., TNF-α, IL-6) by ELISA. Cell viability would be measured using an MTT assay to ensure that the observed effects are not due to cytotoxicity.
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| Animal Protocol |
Specific in vivo animal studies for yuanhuanin are not reported in the available literature. As a natural product, it could be tested in rodent models of inflammation or oxidative stress. For example, mice could be administered yuanhuanin orally or intraperitoneally, and then subjected to a model of acute inflammation (e.g., carrageenan-induced paw edema). The reduction in edema would be measured. However, such studies have not been described in the available sources.
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| ADME/Pharmacokinetics |
Yuanhuanin has a molecular weight of 462.4 g/mol and a molecular formula of C22H22O11. It is a flavonoid glycoside. Its solubility in various solvents is not detailed in the available literature. As a natural product, it is typically stored at 2-8°C. Its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, have not been characterized.
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| Toxicity/Toxicokinetics |
Detailed toxicological data for yuanhuanin have not been reported. As a natural product used for research, it is generally considered to have low toxicity, but comprehensive safety data are not available. Standard laboratory safety precautions should be followed when handling yuanhuanin. It is not a drug and is not intended for human use.
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| References | |
| Additional Infomation |
Reports indicate that Daphne feddei and Wikstroemia canescens have been found, and relevant data is available for reference.
Yuanhuanin is a naturally occurring flavonoid glycoside extracted from various Daphne species, including D. sericea, D. koreana, and D. pedunculata. It is used as a research chemical in life sciences. The compound is of interest for studying the biological activities of flavonoids, including their potential antioxidant, anti-inflammatory, and anticancer properties. Yuanhuanin is not a clinically approved drug and has not entered clinical trials. Its primary value is as a research tool for natural product chemistry and pharmacology. |
| Molecular Formula |
C22H22O11
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|---|---|
| Molecular Weight |
462.4035
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| Exact Mass |
462.116
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| CAS # |
83133-14-6
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| Related CAS # |
83133-14-6;
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| PubChem CID |
179680
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| Appearance |
White to off-white solid powder
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| Density |
1.609±0.06 g/cm3(Predicted)
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| Boiling Point |
817.5±65.0 °C(Predicted)
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| LogP |
0.3
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| Hydrogen Bond Donor Count |
6
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| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
33
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| Complexity |
729
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| Defined Atom Stereocenter Count |
5
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| SMILES |
O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)C1=CC(OC)=CC2OC(C3C=CC(O)=C(O)C=3)=CC(C1=2)=O
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| InChi Key |
ZXVSQQSRCKKYLS-MIUGBVLSSA-N
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| InChi Code |
InChI=1S/C22H22O11/c1-30-10-5-15-18(13(26)7-14(31-15)9-2-3-11(24)12(25)4-9)16(6-10)32-22-21(29)20(28)19(27)17(8-23)33-22/h2-7,17,19-25,27-29H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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| Chemical Name |
2-(3,4-dihydroxyphenyl)-7-methoxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1626 mL | 10.8131 mL | 21.6263 mL | |
| 5 mM | 0.4325 mL | 2.1626 mL | 4.3253 mL | |
| 10 mM | 0.2163 mL | 1.0813 mL | 2.1626 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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