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    YH239-EE
    YH239-EE

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0044
    CAS #: 1364488-67-4Purity ≥98%

    Description: YH239-EE (YH239-EE; YH239EE; YH239 EE), the ethyl ester of YH239, is a novel and highly potent antagonist of p53/MDM2 (murine double minute 2) protein protein interaction. It is also an apoptosis inducer with anticancer activities. 

    References:  ACS Chem Biol. 2014 Mar 21;9(3):802-11.

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    Molecular Weight (MW)504.41
    FormulaC25H27Cl2N3O4
    CAS No.1364488-67-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (198.3 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: 18 mg/mL (35.7 mM)
    Other info

    Synonym: YH239-EE; YH239EE; YH239 EE; YH239 Ethylester;

    Chemical Name: Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate

    InChi Key: OTUBDDRFPQLPKD-UHFFFAOYSA-N

    InChi Code: InChI=1S/C25H27Cl2N3O4/c1-5-34-24(33)21-20(18-11-10-17(27)12-19(18)28-21)22(23(32)29-25(2,3)4)30(14-31)13-15-6-8-16(26)9-7-15/h6-12,14,22,28H,5,13H2,1-4H3,(H,29,32)

    SMILES Code: O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC

    Chemical NameEthyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate


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    In VitroYH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
    In VivoN/A
    Animal modelN/A
    Formulation & DosageN/A
    References[1] Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    YH239-EE

    Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811.


     

     

    YH239-EE



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