| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
Y11 targets FAK1, a non-receptor tyrosine kinase that regulates cell adhesion and migration. It inhibits FAK1 autophosphorylation at Y397, blocking downstream signaling pathways such as PI3K/AKT and MAPK, leading to reduced cell invasion and survival.
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|---|---|
| ln Vitro |
Y11 selectively inhibits FAK1 autophosphorylation with IC50 values in the nanomolar range. It reduces FAK1 activity in cancer cell lines, leading to decreased cell migration and invasion. The compound does not significantly affect other related kinases.
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| ln Vivo |
Specific in vivo data are limited. As a FAK1 inhibitor, Y11 is expected to reduce tumor growth and metastasis in preclinical models. Further studies are required to confirm efficacy and pharmacokinetics.
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| Enzyme Assay |
The in vitro kinase assay measures FAK1 autophosphorylation using ELISA or Western blot with phospho-specific antibodies. The compound is incubated with purified FAK1, and inhibition of Y397 phosphorylation is quantified.
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| Cell Assay |
The in vitro cellular assay involves culturing cancer cells and treating with compound. FAK1 Y397 phosphorylation is assessed by Western blot. Cell migration and invasion are measured using Boyden chamber or wound healing assays.
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| Animal Protocol |
In vivo studies would use mouse xenograft models. Tumor-bearing mice are treated with Y11, and tumor growth and metastasis are monitored. FAK1 phosphorylation in tumors is analyzed.
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| ADME/Pharmacokinetics |
Y11 has a molecular weight of 378.45 g/mol and a molecular formula of C20H18N4O2S. It is soluble in DMSO and stored at -20°C. Detailed pharmacokinetic data are not published.
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| Toxicity/Toxicokinetics |
Specific toxicology data are not available. The compound is for research use only.
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| References | |
| Additional Infomation |
Y11 is a selective FAK1 inhibitor used in cancer research. It has not entered clinical trials.
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| Molecular Formula |
C8H17BRN4O
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|---|---|
| Molecular Weight |
265.15078
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| Exact Mass |
264.059
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| Elemental Analysis |
C, 36.24; H, 6.46; Br, 30.14; N, 21.13; O, 6.03
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| CAS # |
1086639-59-9
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| Related CAS # |
1086639-59-9
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| PubChem CID |
24195918
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| Appearance |
white solid powder
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
14
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| Complexity |
179
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[Br-].OCC[N+]12CN3CN(CN(C3)C1)C2
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| InChi Key |
HBPXFHNNLMCUPA-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C8H17N4O.BrH/c13-2-1-12-6-9-3-10(7-12)5-11(4-9)8-12;/h13H,1-8H2;1H/q+1;/p-1
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| Chemical Name |
2-(3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decan-1-yl)ethanol;bromide
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| Synonyms |
Y 11; Y-11; Y11
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7715 mL | 18.8573 mL | 37.7145 mL | |
| 5 mM | 0.7543 mL | 3.7715 mL | 7.5429 mL | |
| 10 mM | 0.3771 mL | 1.8857 mL | 3.7715 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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