| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Veratryl alcohol does not have a primary pharmacological target. It is a fungal metabolite and a substrate for ligninolytic enzymes such as lignin peroxidase and manganese peroxidase.
|
|---|---|
| ln Vitro |
In vitro, Veratryl alcohol is used as a substrate to measure the activity of ligninolytic enzymes. It is oxidized by lignin peroxidase to veratryl aldehyde, which can be monitored spectrophotometrically.
|
| ln Vivo |
In vivo, Veratryl alcohol is a secondary metabolite produced by lignin-degrading fungi. It is not administered as a therapeutic agent in animals.
|
| Enzyme Assay |
Lignin peroxidase activity is measured using Veratryl alcohol as a substrate. The enzyme is incubated with Veratryl alcohol and H2O2, and the formation of veratryl aldehyde is monitored spectrophotometrically at 310 nm.
|
| Cell Assay |
Not applicable; Veratryl alcohol is not used as a treatment in cell culture experiments. It is used as a substrate in enzymatic assays.
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| Animal Protocol |
Not applicable; Veratryl alcohol is not administered to animals as a therapeutic agent. It is used in studies of fungal metabolism and lignin degradation.
|
| ADME/Pharmacokinetics |
Veratryl alcohol is a small molecule that is metabolized by fungi. It is not a drug and does not have therapeutic pharmacokinetic properties.
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| Toxicity/Toxicokinetics |
Veratryl alcohol is considered relatively non-toxic. It is used as a laboratory reagent with standard safety precautions. No significant toxicity has been reported.
|
| References | |
| Additional Infomation |
(3,4-Dimethoxyphenyl)methanol belongs to the benzyl alcohol class of compounds, in which the hydrogen atoms at the 3 and 4 positions of the benzene ring are replaced by methoxy groups. It is a fungal metabolite. It belongs to the benzyl alcohol, primary alcohol, and dimethoxyphenyl compounds. 3,4-Dimethoxybenzyl alcohol has been reported to be detected in croton (Croton lechleri) and squash (Cucurbita pepo), and relevant data are available for reference.
Veratryl alcohol is a research chemical used in studies of lignin degradation and fungal metabolism. It has no clinical or therapeutic applications. |
| Molecular Formula |
C9H12O3
|
|---|---|
| Molecular Weight |
168.1898
|
| Exact Mass |
168.078
|
| CAS # |
93-03-8
|
| PubChem CID |
7118
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
298.1±0.0 °C at 760 mmHg
|
| Melting Point |
22 °C
|
| Flash Point |
121.7±23.2 °C
|
| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.521
|
| LogP |
0.77
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
12
|
| Complexity |
127
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
OCC1C=C(OC)C(OC)=CC=1
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
Ethanol : ~100 mg/mL (~594.57 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.9457 mL | 29.7283 mL | 59.4566 mL | |
| 5 mM | 1.1891 mL | 5.9457 mL | 11.8913 mL | |
| 10 mM | 0.5946 mL | 2.9728 mL | 5.9457 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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