| Size | Price | Stock | Qty |
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| Targets |
Tyclopyrazoflor targets key pathways essential for insect survival. It is an anthranilamide-based insecticide that interferes with the insect nervous transmission system. The compound's mechanism of action is distinct from existing ryanodine insecticides, as it has a different amide moiety.
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| ln Vitro |
In vitro, Tyclopyrazoflor demonstrates potent pesticidal activity against target insect pests. It has been tested for activity against green peach aphid (Myzus persicae) and sweet potato whitefly (Bemisia tabaci). The compound shows efficacy against cotton whitefly and palm weevil. Detailed IC₅0 or EC₅0 values are not extensively documented in the available literature.
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| ln Vivo |
In vivo activity data for Tyclopyrazoflor indicate efficacy against sap-feeding insect pests. The insecticide is effective against cotton whitefly (Bemisia tabaci) and palm weevil (Rhynchophorus ferrugineus). It shows activity against aphids in crops such as rice. Further field efficacy studies would be needed to fully characterize its performance in agricultural settings.
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| Enzyme Assay |
The in vitro insecticidal activity assay for Tyclopyrazoflor involves exposing target insect pests (such as aphids or whiteflies) to varying concentrations of the compound. Insect mortality is assessed at multiple time points (24, 48, and 72 hours). LC₅0 or EC₅0 values are calculated from dose-response curves. The assay is typically performed on leaf discs or potted plants under controlled environmental conditions.
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| Cell Assay |
For in vitro cell-based assays, insect cell lines (such as Sf9 or High Five cells) are cultured and treated with Tyclopyrazoflor at various concentrations. Cell viability is measured using MTT or other proliferation assays to assess cytotoxicity. The compound's effect on insect nervous system targets may be evaluated using electrophysiological or calcium imaging techniques. Experiments are typically performed in triplicate.
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| Animal Protocol |
In vivo animal studies for Tyclopyrazoflor typically involve whole-plant or field trials on target insect pests. The compound is applied as a foliar spray or soil drench at various concentrations. Insect populations are monitored before and after treatment, and percent control or mortality is calculated. Efficacy is evaluated by comparing treated plots to untreated controls. Environmental fate and non-target organism studies may also be performed.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Tyclopyrazoflor are not extensively documented. The compound has molecular weight 406.9 g/mol. It is an anthranilamide-based compound with a pyridylpyrazole core. The compound is designed for agricultural application as an insecticide. Further detailed physicochemical and PK parameters would require dedicated studies.
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| Toxicity/Toxicokinetics |
Toxicological data for Tyclopyrazoflor indicate that it is designed to be environmentally friendly with a unique mechanism of action. As a research chemical, standard safety precautions should be observed. The compound is for laboratory and agricultural research use only and not intended for human therapeutic applications. Comprehensive toxicology and ecotoxicology profiling would be required for commercial registration.
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| Additional Infomation |
Tyclopyrazoflor belongs to the pyrazole class of compounds. Its structure is 1H-pyrazole, with pyridin-3-yl, chloro, and ethyl{3-[(3,3,3-trifluoropropyl)thio]propionyl}nitrile groups substituted at positions 1, 3, and 4, respectively. It is an insecticide produced by Dow AgroSciences LLC. It is an organofluorine compound, belonging to the pyrazole, pyridine, tertiary amide, organosulfur, and organochlorine classes.
Tyclopyrazoflor (CAS# 1477919-27-9) is a modern pyridylpyrazole insecticide developed by Dow AgroSciences (now Corteva). It is an anthranilamide-based compound first reported in WO2013/162716. The insecticide is effective against cotton whitefly, palm weevil, green peach aphid, and sweet potato whitefly. It has a novel chemical structure distinct from ryanodine insecticides and is not approved for human therapeutic use. |
| Molecular Formula |
C16H18CLF3N4OS
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|---|---|
| Molecular Weight |
406.853531360626
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| Exact Mass |
406.084
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| CAS # |
1477919-27-9
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| PubChem CID |
86700627
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
3.6
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
26
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| Complexity |
458
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
DBHVHTPMRCXCIY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H18ClF3N4OS/c1-2-23(14(25)5-8-26-9-6-16(18,19)20)13-11-24(22-15(13)17)12-4-3-7-21-10-12/h3-4,7,10-11H,2,5-6,8-9H2,1H3
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| Chemical Name |
N-(3-chloro-1-pyridin-3-ylpyrazol-4-yl)-N-ethyl-3-(3,3,3-trifluoropropylsulfanyl)propanamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~307.24 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4579 mL | 12.2895 mL | 24.5791 mL | |
| 5 mM | 0.4916 mL | 2.4579 mL | 4.9158 mL | |
| 10 mM | 0.2458 mL | 1.2290 mL | 2.4579 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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