| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
The primary target of Triflumuron is chitin synthesis in insects. It inhibits the enzyme chitin synthase, which is involved in the production of chitin, a key component of the insect exoskeleton. By inhibiting chitin synthesis, triflumuron prevents the formation of the exoskeleton, leading to the death of the insect during molting. The compound is a contact and stomach poison.
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|---|---|
| ln Vitro |
In vitro, triflumuron has been shown to inhibit chitin synthesis in insect cell cultures. It reduces the incorporation of labeled precursors into chitin. The compound's insecticidal activity has been confirmed in various in vitro models using insect cell lines.
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| ln Vivo |
In vivo, triflumuron is effective in controlling a wide range of insect pests. It is used on crops, forests, and in public health for mosquito control. The compound provides long-lasting control and is effective against both larvae and eggs.
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| Enzyme Assay |
In vitro enzyme or receptor binding (non-cell) assays for triflumuron involve measuring its inhibition of chitin synthase activity. The assay uses a purified chitin synthase enzyme or insect tissue homogenates and a substrate, such as UDP-N-acetylglucosamine. The incorporation of labeled substrate into chitin is measured. The compound is incubated with the enzyme and substrate at varying concentrations, and the IC50 is determined.
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| Cell Assay |
In vitro cell-based assays for triflumuron are performed using insect cell lines. Cells are treated with the compound, and chitin synthesis is measured by the incorporation of labeled precursors. The compound's effects on cell viability and insect development are also assessed.
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| Animal Protocol |
In vivo animal experiments for triflumuron are conducted using insect models, such as larvae of Lepidoptera or Coleoptera. The compound is applied to the insects or to their food source, and mortality and developmental abnormalities are assessed. These studies confirm the compound's efficacy as an insect growth regulator.
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| ADME/Pharmacokinetics |
Pharmacokinetic (PK) properties of triflumuron indicate that it is absorbed by insects through contact or ingestion. The compound has a molecular weight of 358.70 and a molecular formula of C15H10ClF3N2O3. It is a solid at room temperature. It is metabolized in insects and has a relatively long residual activity. The compound is typically applied as a spray.
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| Toxicity/Toxicokinetics |
Toxicology (toxicology) data for triflumuron indicate that it is of low toxicity to mammals. It is not highly toxic by ingestion or dermal exposure. The compound may cause mild skin and eye irritation. It is toxic to aquatic organisms and should be used with caution near water bodies.
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| Additional Infomation |
Trifluralin is a benzoylurea insecticide, belonging to the monochlorobenzene class of compounds. It is an organofluorine compound and also an aromatic ether.
Other information: Triflumuron is a benzoylurea insecticide used in agriculture and public health. It is also known as Alsystin. The compound inhibits chitin synthesis in insects. Its CAS number is 64628-44-0. |
| Molecular Formula |
C15H10CLF3N2O3
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|---|---|
| Molecular Weight |
358.7012
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| Exact Mass |
358.033
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| CAS # |
64628-44-0
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| PubChem CID |
47445
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.5±0.1 g/cm3
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| Melting Point |
188 - 190ºC
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| Index of Refraction |
1.582
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| LogP |
4.55
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
24
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| Complexity |
454
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC(C2=CC=CC=C2Cl)=O
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| InChi Key |
XAIPTRIXGHTTNT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H10ClF3N2O3/c16-12-4-2-1-3-11(12)13(22)21-14(23)20-9-5-7-10(8-6-9)24-15(17,18)19/h1-8H,(H2,20,21,22,23)
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| Chemical Name |
2-chloro-N-[[4-(trifluoromethoxy)phenyl]carbamoyl]benzamide
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| Synonyms |
SIR8514; SIR-8514; SIR 8514
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7878 mL | 13.9392 mL | 27.8784 mL | |
| 5 mM | 0.5576 mL | 2.7878 mL | 5.5757 mL | |
| 10 mM | 0.2788 mL | 1.3939 mL | 2.7878 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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